Relative Involvement of Spinal Opioid Receptors in Physical Dependence on Intrathecal Butorphanol and Morphine
The present study was carried out to investigate the relative involvement of spinal opioid receptors in the development of physical dependence on intrathecal (IT) butorphanol in comparison with IT morphine. Dependence was induced by continuous IT infusion of butorphanol (52 nmol/h) and morphine (26...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1998-08, Vol.60 (4), p.899-907 |
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| creator | Wongchanapai, W. Tsang, B.K. He, Z. Ho, I.K. |
| description | The present study was carried out to investigate the relative involvement of spinal opioid receptors in the development of physical dependence on intrathecal (IT) butorphanol in comparison with IT morphine. Dependence was induced by continuous IT infusion of butorphanol (52 nmol/h) and morphine (26 nmol/h) for 4 days in male Sprague–Dawley rats. Naloxone, CTOP, naltrindole, and nor-binaltorphimine (nor-BNI) were administered IT to precipitate behavioral signs of withdrawal. Administration of IT naloxone produced a significantly greater increase in the profile of withdrawal signs in IT morphine dependence than that in IT butorphanol dependence. An IT nor-BNI challenge elicits behavioral signs of withdrawal only in rats dependent on IT butorphanol, but not in rats dependent on IT morphine. CTOP administered IT precipitated withdrawal signs in IT morphine dependence that were greater than that in IT butorphanol dependence. An IT treatment with naltrindole produced equivalent signs of withdrawal in both IT butorphanol- and morphine-dependent rats. These results suggest that continuous IT butorphanol results in the development of less physical dependence than that of IT morphine. Spinal κ- rather than δ- and μ-opioid receptors play a major role in the development of IT butorphanol dependence, whereas spinal μ-opioid receptors play a more important role than δ-opioid receptors in IT morphine dependence. |
| doi_str_mv | 10.1016/S0091-3057(98)00074-4 |
| format | Article |
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Dependence was induced by continuous IT infusion of butorphanol (52 nmol/h) and morphine (26 nmol/h) for 4 days in male Sprague–Dawley rats. Naloxone, CTOP, naltrindole, and nor-binaltorphimine (nor-BNI) were administered IT to precipitate behavioral signs of withdrawal. Administration of IT naloxone produced a significantly greater increase in the profile of withdrawal signs in IT morphine dependence than that in IT butorphanol dependence. An IT nor-BNI challenge elicits behavioral signs of withdrawal only in rats dependent on IT butorphanol, but not in rats dependent on IT morphine. CTOP administered IT precipitated withdrawal signs in IT morphine dependence that were greater than that in IT butorphanol dependence. An IT treatment with naltrindole produced equivalent signs of withdrawal in both IT butorphanol- and morphine-dependent rats. These results suggest that continuous IT butorphanol results in the development of less physical dependence than that of IT morphine. Spinal κ- rather than δ- and μ-opioid receptors play a major role in the development of IT butorphanol dependence, whereas spinal μ-opioid receptors play a more important role than δ-opioid receptors in IT morphine dependence.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(98)00074-4</identifier><identifier>PMID: 9700974</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Butorphanol ; Butorphanol - administration & dosage ; Drug toxicity and drugs side effects treatment ; Injections, Spinal ; Intrathecal ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Morphine ; Morphine - administration & dosage ; Morphine Dependence - physiopathology ; Narcotic Antagonists - administration & dosage ; Narcotic Antagonists - pharmacology ; Narcotics - administration & dosage ; Opioid-Related Disorders - physiopathology ; Pharmacology. Drug treatments ; Physical dependence ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid - drug effects ; Spinal Cord - physiology ; Substance Withdrawal Syndrome - psychology</subject><ispartof>Pharmacology, biochemistry and behavior, 1998-08, Vol.60 (4), p.899-907</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-f89cf3f9f7a055058b488ef913d379e4c7306705abd580a6d65a563c1be605953</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-3057(98)00074-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2381112$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9700974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wongchanapai, W.</creatorcontrib><creatorcontrib>Tsang, B.K.</creatorcontrib><creatorcontrib>He, Z.</creatorcontrib><creatorcontrib>Ho, I.K.</creatorcontrib><title>Relative Involvement of Spinal Opioid Receptors in Physical Dependence on Intrathecal Butorphanol and Morphine</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The present study was carried out to investigate the relative involvement of spinal opioid receptors in the development of physical dependence on intrathecal (IT) butorphanol in comparison with IT morphine. Dependence was induced by continuous IT infusion of butorphanol (52 nmol/h) and morphine (26 nmol/h) for 4 days in male Sprague–Dawley rats. Naloxone, CTOP, naltrindole, and nor-binaltorphimine (nor-BNI) were administered IT to precipitate behavioral signs of withdrawal. Administration of IT naloxone produced a significantly greater increase in the profile of withdrawal signs in IT morphine dependence than that in IT butorphanol dependence. An IT nor-BNI challenge elicits behavioral signs of withdrawal only in rats dependent on IT butorphanol, but not in rats dependent on IT morphine. CTOP administered IT precipitated withdrawal signs in IT morphine dependence that were greater than that in IT butorphanol dependence. An IT treatment with naltrindole produced equivalent signs of withdrawal in both IT butorphanol- and morphine-dependent rats. These results suggest that continuous IT butorphanol results in the development of less physical dependence than that of IT morphine. Spinal κ- rather than δ- and μ-opioid receptors play a major role in the development of IT butorphanol dependence, whereas spinal μ-opioid receptors play a more important role than δ-opioid receptors in IT morphine dependence.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Butorphanol</subject><subject>Butorphanol - administration & dosage</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Injections, Spinal</subject><subject>Intrathecal</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Morphine</subject><subject>Morphine - administration & dosage</subject><subject>Morphine Dependence - physiopathology</subject><subject>Narcotic Antagonists - administration & dosage</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Narcotics - administration & dosage</subject><subject>Opioid-Related Disorders - physiopathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical dependence</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Opioid - drug effects</subject><subject>Spinal Cord - physiology</subject><subject>Substance Withdrawal Syndrome - psychology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rFDEUQIModa3-hEIeRPRh2mQz-XoSrR8ttFRafQ7Z5IaNzCbTZHah_95Md9lXn0I4596Eg9AZJeeUUHHxQIimHSNcftTqEyFE9l3_Ai2okqzjVMqXaHFUXqM3tf5tUr8U8gSdaNmQ7Bco3cNgp7gDfJ12edjBBtKEc8APY0x2wHdjzNHje3AwTrlUHBP-tX6q0TX4DUZIHpIDnFNbMBU7rWEmX7dNHtc25QHb5PHtfIsJ3qJXwQ4V3h3OU_Tnx_ffl1fdzd3P68svN53rlZi6oLQLLOggLeGccLXqlYKgKfNMauidZERIwu3Kc0Ws8IJbLpijKxCEa85O0Yf93rHkxy3UyWxidTAMNkHeVkOl4JwK3US-F13JtRYIZixxY8uTocTMnc1zZzNHNFqZ586mb3Nnhwe2qw3449QhbOPvD9zWFiQUm1ysR23JFKV02bTPew1ajF2EYqqLc1AfC7jJ-Bz_85F_JyiaSw</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Wongchanapai, W.</creator><creator>Tsang, B.K.</creator><creator>He, Z.</creator><creator>Ho, I.K.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19980801</creationdate><title>Relative Involvement of Spinal Opioid Receptors in Physical Dependence on Intrathecal Butorphanol and Morphine</title><author>Wongchanapai, W. ; Tsang, B.K. ; He, Z. ; Ho, I.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-f89cf3f9f7a055058b488ef913d379e4c7306705abd580a6d65a563c1be605953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Butorphanol</topic><topic>Butorphanol - administration & dosage</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Injections, Spinal</topic><topic>Intrathecal</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Morphine</topic><topic>Morphine - administration & dosage</topic><topic>Morphine Dependence - physiopathology</topic><topic>Narcotic Antagonists - administration & dosage</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Narcotics - administration & dosage</topic><topic>Opioid-Related Disorders - physiopathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical dependence</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Opioid - drug effects</topic><topic>Spinal Cord - physiology</topic><topic>Substance Withdrawal Syndrome - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wongchanapai, W.</creatorcontrib><creatorcontrib>Tsang, B.K.</creatorcontrib><creatorcontrib>He, Z.</creatorcontrib><creatorcontrib>Ho, I.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wongchanapai, W.</au><au>Tsang, B.K.</au><au>He, Z.</au><au>Ho, I.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative Involvement of Spinal Opioid Receptors in Physical Dependence on Intrathecal Butorphanol and Morphine</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>60</volume><issue>4</issue><spage>899</spage><epage>907</epage><pages>899-907</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The present study was carried out to investigate the relative involvement of spinal opioid receptors in the development of physical dependence on intrathecal (IT) butorphanol in comparison with IT morphine. Dependence was induced by continuous IT infusion of butorphanol (52 nmol/h) and morphine (26 nmol/h) for 4 days in male Sprague–Dawley rats. Naloxone, CTOP, naltrindole, and nor-binaltorphimine (nor-BNI) were administered IT to precipitate behavioral signs of withdrawal. Administration of IT naloxone produced a significantly greater increase in the profile of withdrawal signs in IT morphine dependence than that in IT butorphanol dependence. An IT nor-BNI challenge elicits behavioral signs of withdrawal only in rats dependent on IT butorphanol, but not in rats dependent on IT morphine. CTOP administered IT precipitated withdrawal signs in IT morphine dependence that were greater than that in IT butorphanol dependence. An IT treatment with naltrindole produced equivalent signs of withdrawal in both IT butorphanol- and morphine-dependent rats. These results suggest that continuous IT butorphanol results in the development of less physical dependence than that of IT morphine. 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| subjects | Animals Biological and medical sciences Butorphanol Butorphanol - administration & dosage Drug toxicity and drugs side effects treatment Injections, Spinal Intrathecal Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Morphine Morphine - administration & dosage Morphine Dependence - physiopathology Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology Narcotics - administration & dosage Opioid-Related Disorders - physiopathology Pharmacology. Drug treatments Physical dependence Rats Rats, Sprague-Dawley Receptors, Opioid - drug effects Spinal Cord - physiology Substance Withdrawal Syndrome - psychology |
| title | Relative Involvement of Spinal Opioid Receptors in Physical Dependence on Intrathecal Butorphanol and Morphine |
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