Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt
Background & Aims Chemokines, such as CXCR3‐ligands, have been identified to play an important role during hepatic injury, inflammation and fibrosis. While CXCL9 is associated with survival in patients receiving transjugular intrahepatic portosystemic shunt (TIPS), the role of CXCL11 in severe p...
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| Veröffentlicht in: | Liver international 2016-03, Vol.36 (3), p.386-394 |
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| creator | Berres, Marie-Luise Lehmann, Jennifer Jansen, Christian Görtzen, Jan Meyer, Carsten Thomas, Daniel Zimmermann, Henning W. Kroy, Daniela Schumacher, Fabienne Strassburg, Christian P. Sauerbruch, Tilman Trautwein, Christian Wasmuth, Hermann E. Trebicka, Jonel |
| description | Background & Aims
Chemokines, such as CXCR3‐ligands, have been identified to play an important role during hepatic injury, inflammation and fibrosis. While CXCL9 is associated with survival in patients receiving transjugular intrahepatic portosystemic shunt (TIPS), the role of CXCL11 in severe portal hypertension remains unknown.
Methods
CXCL11‐levels were measured in 136 patients with liver diseases, and 63 healthy controls. In further 47 cirrhotic patients receiving TIPS, CXCL11 levels were measured in portal and hepatic veins at TIPS insertion by cytometric bead array. CXCL11‐levels were measured in 23 patients in cubital vein and right atrium, whereas in 24 patients in portal and hepatic blood at an invasive reevaluation.
Results
CXCL11‐levels were increased with the severity of liver fibrosis. CXCL11‐levels from portal, hepatic and cubital veins and right atrium showed a highly significant correlation among each other in these patients. Furthermore, levels of CXCL11 from the right atrium were significantly higher than those from cubital vein. Interestingly, patients with alcoholic cirrhosis had significantly lower CXCL11‐levels, than other aetiologies of cirrhosis. After TIPS, CXCL11 levels correlated with the degree of portal pressure and patients with higher CXCL11‐levels in portal and hepatic veins showed higher mortality. Multivariate analysis revealed hepatic CXCL11‐levels before TIPS, creatinine and age as independent predictors for survival in TIPS patients, whereas MELD score and low portal CXCL11‐levels after TIPS predicted long‐term survival.
Conclusion
CXCL11 levels are mainly increased in patients with non‐alcoholic cirrhosis and high portal pressure. Moreover, levels of CXCL11 might predict long‐time survival of cirrhotic patients bearing TIPS. |
| doi_str_mv | 10.1111/liv.12922 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1765114124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1765114124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4332-82797ef058ad03775acb8ae170343708ab34e29cd7ad4dcd8cb26da8232c5b3a3</originalsourceid><addsrcrecordid>eNp10M1O3DAUBWALtQJKWfAClZewCPgniZ1lFVFAGlGporQ7y7HvEIOTTG1n6Gz75DUdmF29ub7Sd8_iIHRCyTnN78K79TllDWN76JCWQhaccfpu92f8AH2I8ZEQ2jQV3UcHrGaUEVEdoj9tD8P05EbAp23xs2jxMCW3PMPePejRYkqxhzX4iFcBrDMJxzms3Vp77EZsXAh99gavdHIwpoifXepxCnqMj_PD7HXILq89vIjsppCmuIkJhrzFfh7TR_R-qX2E49d5hL5_ubxrr4vF16ub9vOiMCXnrJBMNAKWpJLaEi5EpU0nNVBBeMkFkbrjJbDGWKFtaY2VpmO11ZJxZqqOa36ETre5qzD9miEmNbhowHs9wjRHRUVdUVpSVmZ6tqUmTDEGWKpVcIMOG0WJeqlc5crVv8qz_fQaO3cD2J186ziDiy14dh42_09Si5v7t8hie-FyT793Fzo8qVpwUakft1fq7vZafpP3tWr4X0ajnBw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1765114124</pqid></control><display><type>article</type><title>Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Berres, Marie-Luise ; Lehmann, Jennifer ; Jansen, Christian ; Görtzen, Jan ; Meyer, Carsten ; Thomas, Daniel ; Zimmermann, Henning W. ; Kroy, Daniela ; Schumacher, Fabienne ; Strassburg, Christian P. ; Sauerbruch, Tilman ; Trautwein, Christian ; Wasmuth, Hermann E. ; Trebicka, Jonel</creator><creatorcontrib>Berres, Marie-Luise ; Lehmann, Jennifer ; Jansen, Christian ; Görtzen, Jan ; Meyer, Carsten ; Thomas, Daniel ; Zimmermann, Henning W. ; Kroy, Daniela ; Schumacher, Fabienne ; Strassburg, Christian P. ; Sauerbruch, Tilman ; Trautwein, Christian ; Wasmuth, Hermann E. ; Trebicka, Jonel</creatorcontrib><description>Background & Aims
Chemokines, such as CXCR3‐ligands, have been identified to play an important role during hepatic injury, inflammation and fibrosis. While CXCL9 is associated with survival in patients receiving transjugular intrahepatic portosystemic shunt (TIPS), the role of CXCL11 in severe portal hypertension remains unknown.
Methods
CXCL11‐levels were measured in 136 patients with liver diseases, and 63 healthy controls. In further 47 cirrhotic patients receiving TIPS, CXCL11 levels were measured in portal and hepatic veins at TIPS insertion by cytometric bead array. CXCL11‐levels were measured in 23 patients in cubital vein and right atrium, whereas in 24 patients in portal and hepatic blood at an invasive reevaluation.
Results
CXCL11‐levels were increased with the severity of liver fibrosis. CXCL11‐levels from portal, hepatic and cubital veins and right atrium showed a highly significant correlation among each other in these patients. Furthermore, levels of CXCL11 from the right atrium were significantly higher than those from cubital vein. Interestingly, patients with alcoholic cirrhosis had significantly lower CXCL11‐levels, than other aetiologies of cirrhosis. After TIPS, CXCL11 levels correlated with the degree of portal pressure and patients with higher CXCL11‐levels in portal and hepatic veins showed higher mortality. Multivariate analysis revealed hepatic CXCL11‐levels before TIPS, creatinine and age as independent predictors for survival in TIPS patients, whereas MELD score and low portal CXCL11‐levels after TIPS predicted long‐term survival.
Conclusion
CXCL11 levels are mainly increased in patients with non‐alcoholic cirrhosis and high portal pressure. Moreover, levels of CXCL11 might predict long‐time survival of cirrhotic patients bearing TIPS.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.12922</identifier><identifier>PMID: 26212075</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Biomarkers - blood ; Case-Control Studies ; chemokine (C-X-C motif) ligand 11 ; Chemokine CXCL11 - blood ; chemokines ; cirrhosis ; Female ; Humans ; Hypertension, Portal - blood ; Hypertension, Portal - etiology ; Hypertension, Portal - mortality ; Hypertension, Portal - surgery ; Kaplan-Meier Estimate ; Liver Cirrhosis - complications ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - mortality ; Male ; Middle Aged ; Multivariate Analysis ; portal hypertension ; Portasystemic Shunt, Transjugular Intrahepatic - adverse effects ; Portasystemic Shunt, Transjugular Intrahepatic - mortality ; Predictive Value of Tests ; Proportional Hazards Models ; Risk Factors ; Severity of Illness Index ; Time Factors ; transjugular intrahepatic portosystemic shunt ; Treatment Outcome</subject><ispartof>Liver international, 2016-03, Vol.36 (3), p.386-394</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4332-82797ef058ad03775acb8ae170343708ab34e29cd7ad4dcd8cb26da8232c5b3a3</citedby><cites>FETCH-LOGICAL-c4332-82797ef058ad03775acb8ae170343708ab34e29cd7ad4dcd8cb26da8232c5b3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fliv.12922$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fliv.12922$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26212075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berres, Marie-Luise</creatorcontrib><creatorcontrib>Lehmann, Jennifer</creatorcontrib><creatorcontrib>Jansen, Christian</creatorcontrib><creatorcontrib>Görtzen, Jan</creatorcontrib><creatorcontrib>Meyer, Carsten</creatorcontrib><creatorcontrib>Thomas, Daniel</creatorcontrib><creatorcontrib>Zimmermann, Henning W.</creatorcontrib><creatorcontrib>Kroy, Daniela</creatorcontrib><creatorcontrib>Schumacher, Fabienne</creatorcontrib><creatorcontrib>Strassburg, Christian P.</creatorcontrib><creatorcontrib>Sauerbruch, Tilman</creatorcontrib><creatorcontrib>Trautwein, Christian</creatorcontrib><creatorcontrib>Wasmuth, Hermann E.</creatorcontrib><creatorcontrib>Trebicka, Jonel</creatorcontrib><title>Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background & Aims
Chemokines, such as CXCR3‐ligands, have been identified to play an important role during hepatic injury, inflammation and fibrosis. While CXCL9 is associated with survival in patients receiving transjugular intrahepatic portosystemic shunt (TIPS), the role of CXCL11 in severe portal hypertension remains unknown.
Methods
CXCL11‐levels were measured in 136 patients with liver diseases, and 63 healthy controls. In further 47 cirrhotic patients receiving TIPS, CXCL11 levels were measured in portal and hepatic veins at TIPS insertion by cytometric bead array. CXCL11‐levels were measured in 23 patients in cubital vein and right atrium, whereas in 24 patients in portal and hepatic blood at an invasive reevaluation.
Results
CXCL11‐levels were increased with the severity of liver fibrosis. CXCL11‐levels from portal, hepatic and cubital veins and right atrium showed a highly significant correlation among each other in these patients. Furthermore, levels of CXCL11 from the right atrium were significantly higher than those from cubital vein. Interestingly, patients with alcoholic cirrhosis had significantly lower CXCL11‐levels, than other aetiologies of cirrhosis. After TIPS, CXCL11 levels correlated with the degree of portal pressure and patients with higher CXCL11‐levels in portal and hepatic veins showed higher mortality. Multivariate analysis revealed hepatic CXCL11‐levels before TIPS, creatinine and age as independent predictors for survival in TIPS patients, whereas MELD score and low portal CXCL11‐levels after TIPS predicted long‐term survival.
Conclusion
CXCL11 levels are mainly increased in patients with non‐alcoholic cirrhosis and high portal pressure. Moreover, levels of CXCL11 might predict long‐time survival of cirrhotic patients bearing TIPS.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>chemokine (C-X-C motif) ligand 11</subject><subject>Chemokine CXCL11 - blood</subject><subject>chemokines</subject><subject>cirrhosis</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Portal - blood</subject><subject>Hypertension, Portal - etiology</subject><subject>Hypertension, Portal - mortality</subject><subject>Hypertension, Portal - surgery</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>portal hypertension</subject><subject>Portasystemic Shunt, Transjugular Intrahepatic - adverse effects</subject><subject>Portasystemic Shunt, Transjugular Intrahepatic - mortality</subject><subject>Predictive Value of Tests</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>transjugular intrahepatic portosystemic shunt</subject><subject>Treatment Outcome</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1O3DAUBWALtQJKWfAClZewCPgniZ1lFVFAGlGporQ7y7HvEIOTTG1n6Gz75DUdmF29ub7Sd8_iIHRCyTnN78K79TllDWN76JCWQhaccfpu92f8AH2I8ZEQ2jQV3UcHrGaUEVEdoj9tD8P05EbAp23xs2jxMCW3PMPePejRYkqxhzX4iFcBrDMJxzms3Vp77EZsXAh99gavdHIwpoifXepxCnqMj_PD7HXILq89vIjsppCmuIkJhrzFfh7TR_R-qX2E49d5hL5_ubxrr4vF16ub9vOiMCXnrJBMNAKWpJLaEi5EpU0nNVBBeMkFkbrjJbDGWKFtaY2VpmO11ZJxZqqOa36ETre5qzD9miEmNbhowHs9wjRHRUVdUVpSVmZ6tqUmTDEGWKpVcIMOG0WJeqlc5crVv8qz_fQaO3cD2J186ziDiy14dh42_09Si5v7t8hie-FyT793Fzo8qVpwUakft1fq7vZafpP3tWr4X0ajnBw</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Berres, Marie-Luise</creator><creator>Lehmann, Jennifer</creator><creator>Jansen, Christian</creator><creator>Görtzen, Jan</creator><creator>Meyer, Carsten</creator><creator>Thomas, Daniel</creator><creator>Zimmermann, Henning W.</creator><creator>Kroy, Daniela</creator><creator>Schumacher, Fabienne</creator><creator>Strassburg, Christian P.</creator><creator>Sauerbruch, Tilman</creator><creator>Trautwein, Christian</creator><creator>Wasmuth, Hermann E.</creator><creator>Trebicka, Jonel</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt</title><author>Berres, Marie-Luise ; Lehmann, Jennifer ; Jansen, Christian ; Görtzen, Jan ; Meyer, Carsten ; Thomas, Daniel ; Zimmermann, Henning W. ; Kroy, Daniela ; Schumacher, Fabienne ; Strassburg, Christian P. ; Sauerbruch, Tilman ; Trautwein, Christian ; Wasmuth, Hermann E. ; Trebicka, Jonel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4332-82797ef058ad03775acb8ae170343708ab34e29cd7ad4dcd8cb26da8232c5b3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>chemokine (C-X-C motif) ligand 11</topic><topic>Chemokine CXCL11 - blood</topic><topic>chemokines</topic><topic>cirrhosis</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Portal - blood</topic><topic>Hypertension, Portal - etiology</topic><topic>Hypertension, Portal - mortality</topic><topic>Hypertension, Portal - surgery</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>portal hypertension</topic><topic>Portasystemic Shunt, Transjugular Intrahepatic - adverse effects</topic><topic>Portasystemic Shunt, Transjugular Intrahepatic - mortality</topic><topic>Predictive Value of Tests</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>transjugular intrahepatic portosystemic shunt</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berres, Marie-Luise</creatorcontrib><creatorcontrib>Lehmann, Jennifer</creatorcontrib><creatorcontrib>Jansen, Christian</creatorcontrib><creatorcontrib>Görtzen, Jan</creatorcontrib><creatorcontrib>Meyer, Carsten</creatorcontrib><creatorcontrib>Thomas, Daniel</creatorcontrib><creatorcontrib>Zimmermann, Henning W.</creatorcontrib><creatorcontrib>Kroy, Daniela</creatorcontrib><creatorcontrib>Schumacher, Fabienne</creatorcontrib><creatorcontrib>Strassburg, Christian P.</creatorcontrib><creatorcontrib>Sauerbruch, Tilman</creatorcontrib><creatorcontrib>Trautwein, Christian</creatorcontrib><creatorcontrib>Wasmuth, Hermann E.</creatorcontrib><creatorcontrib>Trebicka, Jonel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berres, Marie-Luise</au><au>Lehmann, Jennifer</au><au>Jansen, Christian</au><au>Görtzen, Jan</au><au>Meyer, Carsten</au><au>Thomas, Daniel</au><au>Zimmermann, Henning W.</au><au>Kroy, Daniela</au><au>Schumacher, Fabienne</au><au>Strassburg, Christian P.</au><au>Sauerbruch, Tilman</au><au>Trautwein, Christian</au><au>Wasmuth, Hermann E.</au><au>Trebicka, Jonel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2016-03</date><risdate>2016</risdate><volume>36</volume><issue>3</issue><spage>386</spage><epage>394</epage><pages>386-394</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background & Aims
Chemokines, such as CXCR3‐ligands, have been identified to play an important role during hepatic injury, inflammation and fibrosis. While CXCL9 is associated with survival in patients receiving transjugular intrahepatic portosystemic shunt (TIPS), the role of CXCL11 in severe portal hypertension remains unknown.
Methods
CXCL11‐levels were measured in 136 patients with liver diseases, and 63 healthy controls. In further 47 cirrhotic patients receiving TIPS, CXCL11 levels were measured in portal and hepatic veins at TIPS insertion by cytometric bead array. CXCL11‐levels were measured in 23 patients in cubital vein and right atrium, whereas in 24 patients in portal and hepatic blood at an invasive reevaluation.
Results
CXCL11‐levels were increased with the severity of liver fibrosis. CXCL11‐levels from portal, hepatic and cubital veins and right atrium showed a highly significant correlation among each other in these patients. Furthermore, levels of CXCL11 from the right atrium were significantly higher than those from cubital vein. Interestingly, patients with alcoholic cirrhosis had significantly lower CXCL11‐levels, than other aetiologies of cirrhosis. After TIPS, CXCL11 levels correlated with the degree of portal pressure and patients with higher CXCL11‐levels in portal and hepatic veins showed higher mortality. Multivariate analysis revealed hepatic CXCL11‐levels before TIPS, creatinine and age as independent predictors for survival in TIPS patients, whereas MELD score and low portal CXCL11‐levels after TIPS predicted long‐term survival.
Conclusion
CXCL11 levels are mainly increased in patients with non‐alcoholic cirrhosis and high portal pressure. Moreover, levels of CXCL11 might predict long‐time survival of cirrhotic patients bearing TIPS.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26212075</pmid><doi>10.1111/liv.12922</doi><tpages>9</tpages></addata></record> |
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| ispartof | Liver international, 2016-03, Vol.36 (3), p.386-394 |
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| subjects | Adult Aged Biomarkers - blood Case-Control Studies chemokine (C-X-C motif) ligand 11 Chemokine CXCL11 - blood chemokines cirrhosis Female Humans Hypertension, Portal - blood Hypertension, Portal - etiology Hypertension, Portal - mortality Hypertension, Portal - surgery Kaplan-Meier Estimate Liver Cirrhosis - complications Liver Cirrhosis - diagnosis Liver Cirrhosis - mortality Male Middle Aged Multivariate Analysis portal hypertension Portasystemic Shunt, Transjugular Intrahepatic - adverse effects Portasystemic Shunt, Transjugular Intrahepatic - mortality Predictive Value of Tests Proportional Hazards Models Risk Factors Severity of Illness Index Time Factors transjugular intrahepatic portosystemic shunt Treatment Outcome |
| title | Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt |
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