Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology in situ ; here the authors have found that expression of a single gene, Hoxb5 , defines haematopoietic stem cells with long-term reconstitutio...

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Veröffentlicht in:	Nature (London) 2016-02, Vol.530 (7589), p.223-227
Hauptverfasser:	Chen, James Y., Miyanishi, Masanori, Wang, Sean K., Yamazaki, Satoshi, Sinha, Rahul, Kao, Kevin S., Seita, Jun, Sahoo, Debashis, Nakauchi, Hiromitsu, Weissman, Irving L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/1542 631/532/2139 Animals Antigens, CD - metabolism Biomarkers - analysis Bone Marrow - metabolism Cadherins - metabolism Cell interaction Cell Self Renewal Gene Expression Regulation Genes, Reporter - genetics Health aspects Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humanities and Social Sciences Immunophenotyping letter Male Mice Mice, Inbred C57BL multidisciplinary Observations Science Stem Cell Niche
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