Prevention Effect of Thymosin-alpha1 Aganist Early Ventilator-associated Pneumonia in Patients with Mechanical Ventilation
To investigate the preventive effects of thymosin-alpha1 against early ventilator-associated pneumonia (VAP) in the patients with mechanical ventilation. Fifty two patients with expectancy of mechanical ventilation over 48 h were divided into routine therapy group (n=26) and thymosin therapy group (...
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| Veröffentlicht in: | Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban 2015-11, Vol.46 (6), p.957-959 |
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| container_title | Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban |
| container_volume | 46 |
| creator | Zhang, Song-song Li, Kun Wang, Yu-hui Ye, Ba-ning Pan, Yu Shi, Xian-qing |
| description | To investigate the preventive effects of thymosin-alpha1 against early ventilator-associated pneumonia (VAP) in the patients with mechanical ventilation.
Fifty two patients with expectancy of mechanical ventilation over 48 h were divided into routine therapy group (n=26) and thymosin therapy group (n= 26) in random. The patients in routine therapy group were given intensive care unit (ICU) conventional treatment, and the patients in thymosin therapy group were given thymosin treatment additionally (1.6 mg subcutaneous injection, qd X 7 d). The incidence and occurrence time of VAP were observed, and the time of mechanical ventilation and ICU stay were recorded. The levels of CD3+, CD4+, CD4+ /CD8+ T lymphocyte, CD14+ mononuclear cell human leukocyte antigens-DR (CD14+ HLA-DR) and procalcitonin (PCT) were detected before mechanical ventilation and at the 3d and 7th d after mechanical ventilation.
The base line including the level of immunologic function had no difference between the two groups (P>0.05). The inc |
| format | Article |
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Fifty two patients with expectancy of mechanical ventilation over 48 h were divided into routine therapy group (n=26) and thymosin therapy group (n= 26) in random. The patients in routine therapy group were given intensive care unit (ICU) conventional treatment, and the patients in thymosin therapy group were given thymosin treatment additionally (1.6 mg subcutaneous injection, qd X 7 d). The incidence and occurrence time of VAP were observed, and the time of mechanical ventilation and ICU stay were recorded. The levels of CD3+, CD4+, CD4+ /CD8+ T lymphocyte, CD14+ mononuclear cell human leukocyte antigens-DR (CD14+ HLA-DR) and procalcitonin (PCT) were detected before mechanical ventilation and at the 3d and 7th d after mechanical ventilation.
The base line including the level of immunologic function had no difference between the two groups (P>0.05). The inc</description><identifier>ISSN: 1672-173X</identifier><identifier>PMID: 26867337</identifier><language>chi</language><publisher>China</publisher><subject>Calcitonin - blood ; Calcitonin Gene-Related Peptide ; Cholecalciferol - analogs & derivatives ; Cholecalciferol - immunology ; HLA-DR Antigens - blood ; Humans ; Intensive Care Units ; Lipopolysaccharide Receptors - metabolism ; Pneumonia, Ventilator-Associated - prevention & control ; Protein Precursors - blood ; Respiration, Artificial ; Thymosin - analogs & derivatives ; Thymosin - therapeutic use</subject><ispartof>Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban, 2015-11, Vol.46 (6), p.957-959</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26867337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Song-song</creatorcontrib><creatorcontrib>Li, Kun</creatorcontrib><creatorcontrib>Wang, Yu-hui</creatorcontrib><creatorcontrib>Ye, Ba-ning</creatorcontrib><creatorcontrib>Pan, Yu</creatorcontrib><creatorcontrib>Shi, Xian-qing</creatorcontrib><title>Prevention Effect of Thymosin-alpha1 Aganist Early Ventilator-associated Pneumonia in Patients with Mechanical Ventilation</title><title>Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban</title><addtitle>Sichuan Da Xue Xue Bao Yi Xue Ban</addtitle><description>To investigate the preventive effects of thymosin-alpha1 against early ventilator-associated pneumonia (VAP) in the patients with mechanical ventilation.
Fifty two patients with expectancy of mechanical ventilation over 48 h were divided into routine therapy group (n=26) and thymosin therapy group (n= 26) in random. The patients in routine therapy group were given intensive care unit (ICU) conventional treatment, and the patients in thymosin therapy group were given thymosin treatment additionally (1.6 mg subcutaneous injection, qd X 7 d). The incidence and occurrence time of VAP were observed, and the time of mechanical ventilation and ICU stay were recorded. The levels of CD3+, CD4+, CD4+ /CD8+ T lymphocyte, CD14+ mononuclear cell human leukocyte antigens-DR (CD14+ HLA-DR) and procalcitonin (PCT) were detected before mechanical ventilation and at the 3d and 7th d after mechanical ventilation.
The base line including the level of immunologic function had no difference between the two groups (P>0.05). The inc</description><subject>Calcitonin - blood</subject><subject>Calcitonin Gene-Related Peptide</subject><subject>Cholecalciferol - analogs & derivatives</subject><subject>Cholecalciferol - immunology</subject><subject>HLA-DR Antigens - blood</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Lipopolysaccharide Receptors - metabolism</subject><subject>Pneumonia, Ventilator-Associated - prevention & control</subject><subject>Protein Precursors - blood</subject><subject>Respiration, Artificial</subject><subject>Thymosin - analogs & derivatives</subject><subject>Thymosin - therapeutic use</subject><issn>1672-173X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAURTOAaFX6F5BHlkh5cRMnY1WVD6mIDBVii16cZ2LJsUPsgMqvJ4jCdJdzz5XuRbSEXKQxCP66iNbe6yZJABJeFuIqWqR5kQvOxTL6qkb6IBu0s2yvFMnAnGLH7tQ7r22MZugQ2PYNrfaB7XE0J_bywxsMbozReyc1BmpZZWnqndXItGUVBj1Tnn3q0LEnkt0skGj-u_PedXSp0Hhan3MVHe_2x91DfHi-f9xtD_GQ5SJOQUG2AakgQcWFTIA2wHMhihJ5W6RCUFEKyoAa2bRQJAhQtG25kZlqSwC-im5_tcPo3ifyoe61l2QMWnKTr0HkGcydNJvRmzM6NT219TDqHsdT_XcX_wanY2gJ</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Zhang, Song-song</creator><creator>Li, Kun</creator><creator>Wang, Yu-hui</creator><creator>Ye, Ba-ning</creator><creator>Pan, Yu</creator><creator>Shi, Xian-qing</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>Prevention Effect of Thymosin-alpha1 Aganist Early Ventilator-associated Pneumonia in Patients with Mechanical Ventilation</title><author>Zhang, Song-song ; Li, Kun ; Wang, Yu-hui ; Ye, Ba-ning ; Pan, Yu ; Shi, Xian-qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p567-21f1541cf10af37c01e41367789a3d8277e897e51ebcbd180a118dd94c5fd9113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2015</creationdate><topic>Calcitonin - blood</topic><topic>Calcitonin Gene-Related Peptide</topic><topic>Cholecalciferol - analogs & derivatives</topic><topic>Cholecalciferol - immunology</topic><topic>HLA-DR Antigens - blood</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Lipopolysaccharide Receptors - metabolism</topic><topic>Pneumonia, Ventilator-Associated - prevention & control</topic><topic>Protein Precursors - blood</topic><topic>Respiration, Artificial</topic><topic>Thymosin - analogs & derivatives</topic><topic>Thymosin - therapeutic use</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Song-song</creatorcontrib><creatorcontrib>Li, Kun</creatorcontrib><creatorcontrib>Wang, Yu-hui</creatorcontrib><creatorcontrib>Ye, Ba-ning</creatorcontrib><creatorcontrib>Pan, Yu</creatorcontrib><creatorcontrib>Shi, Xian-qing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Song-song</au><au>Li, Kun</au><au>Wang, Yu-hui</au><au>Ye, Ba-ning</au><au>Pan, Yu</au><au>Shi, Xian-qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention Effect of Thymosin-alpha1 Aganist Early Ventilator-associated Pneumonia in Patients with Mechanical Ventilation</atitle><jtitle>Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban</jtitle><addtitle>Sichuan Da Xue Xue Bao Yi Xue Ban</addtitle><date>2015-11</date><risdate>2015</risdate><volume>46</volume><issue>6</issue><spage>957</spage><epage>959</epage><pages>957-959</pages><issn>1672-173X</issn><abstract>To investigate the preventive effects of thymosin-alpha1 against early ventilator-associated pneumonia (VAP) in the patients with mechanical ventilation.
Fifty two patients with expectancy of mechanical ventilation over 48 h were divided into routine therapy group (n=26) and thymosin therapy group (n= 26) in random. The patients in routine therapy group were given intensive care unit (ICU) conventional treatment, and the patients in thymosin therapy group were given thymosin treatment additionally (1.6 mg subcutaneous injection, qd X 7 d). The incidence and occurrence time of VAP were observed, and the time of mechanical ventilation and ICU stay were recorded. The levels of CD3+, CD4+, CD4+ /CD8+ T lymphocyte, CD14+ mononuclear cell human leukocyte antigens-DR (CD14+ HLA-DR) and procalcitonin (PCT) were detected before mechanical ventilation and at the 3d and 7th d after mechanical ventilation.
The base line including the level of immunologic function had no difference between the two groups (P>0.05). The inc</abstract><cop>China</cop><pmid>26867337</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban, 2015-11, Vol.46 (6), p.957-959 |
| issn | 1672-173X |
| language | chi |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Calcitonin - blood Calcitonin Gene-Related Peptide Cholecalciferol - analogs & derivatives Cholecalciferol - immunology HLA-DR Antigens - blood Humans Intensive Care Units Lipopolysaccharide Receptors - metabolism Pneumonia, Ventilator-Associated - prevention & control Protein Precursors - blood Respiration, Artificial Thymosin - analogs & derivatives Thymosin - therapeutic use |
| title | Prevention Effect of Thymosin-alpha1 Aganist Early Ventilator-associated Pneumonia in Patients with Mechanical Ventilation |
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