Icariin inhibits atherosclerosis progress in Apoe null mice by downregulating CX3CR1 in macrophage

Horny Goat Weed is a commonly used in Chinese herbal medicine. And it is used in multiple kinds of diseases including cardiovascular diseases. Icariin is the major component isolated from Horny Goat Weed. It is reported to have lipid-lowering effect. In atherosclerosis, icariin attenuate the enhance...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-02, Vol.470 (4), p.845-850
Hauptverfasser:	Wang, Yao, Wang, Yun-Shan, Song, Shu-Liang, Liang, Hao, Ji, Ai-Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoe null mice Apolipoproteins E - genetics Apolipoproteins E - immunology Atherosclerosis Atherosclerosis - immunology Atherosclerosis - pathology Atherosclerosis - prevention & control chemokine CX3CL1 Chemokine CX3CL1 - immunology CX3C Chemokine Receptor 1 CX3CR1 diet Disease Progression Dose-Response Relationship, Drug Down-Regulation - drug effects Down-Regulation - immunology Flavonoids - administration & dosage gene expression regulation genes herbal medicines Icariin lipemic effect macrophages Macrophages - immunology Male Mice Mice, Knockout microarray technology Receptors, Chemokine - immunology weeds
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