Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques

Abstract Background The aim of the study was to analyze histone acetylation, methylation, and the expression of their corresponding transferases in atherosclerotic plaques of patients with carotid artery stenosis. Methods Atherosclerotic tissue from our biobank ( n = 80) was divided into various seg...

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Veröffentlicht in:	Cardiovascular pathology 2016-03, Vol.25 (2), p.79-86
Hauptverfasser:	Greißel, Anna, Culmes, Mihaela, Burgkart, Rainer, Zimmermann, Alexander, Eckstein, Hans-Henning, Zernecke, Alma, Pelisek, Jaroslav
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Aged Atherosclerosis Carotid artery Carotid Artery Diseases - metabolism Carotid Artery Diseases - pathology DNA Methylation Epigenetics Female Histone acetylation and methylation Histones - metabolism Humans Immunohistochemistry Male Methyl- and acetyltransferases Middle Aged Pathology Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Real-Time Polymerase Chain Reaction
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