Dissemination of the mcr-1 colistin resistance gene

Broader distribution--in terms of geography and bacterial genera--of plasmid-associated mcr-1 is evident because it has now been identified outside Asia.1 Saliently, we describe its presence in an important foodborne pathogen recovered from food and animal environments and associated with well described phenotypic resistance (by disk diffusion, broth microdilution, and concentration gradient strips). 2013LSAL02374 12CEB4337SAL 12CEB2196SAL 2013LSAL04524 Serotype Derby Paratyphi B Paratyphi B 1,4,[5],12:i:- Year 2013 2012 2012 2013 Sample type Chipolata sausage Ready-to-cook guinea fowl pie Chicken breast with skin Boot swabs from broiler farm French department 62 56 85 01 AMP Non-res Non-res Non-res Res AMC Non-res Non-res Non-res Non-res CAZ Non-res Non-res Non-res Non-res CHL Res Res Res Res CEF Non-res Non-res Non-res Non-res CIP Non-res Res Res Non-res CST Res Res Res Res CTX Non-res Non-res Non-res Non-res GEN Non-res Res Res Res KAN Non-res Non-res Non-res Non-res NAL Non-res Res Res Non-res OFX Non-res Non-res Non-res Non-res STR Res Res Res Res SSS Res Res Res Res SXT Res Res Res Res TET Res Res Res Res GenBank accession number LNCZ00000000 LKJK00000000 LKJJ00000000 LKJD00000000 Plasmid replicon harbouring mcr-1 IncP IncX4 IncX4 IncP Table Isolate information for mcr-1 positive isolates selected for whole genome sequencing AMP=ampicillin.