New therapeutic agents for chronic hepatitis B

Summary The treatment goal for chronic hepatitis B is true eradication of the hepatitis B virus, but this is rarely achieved with first-line treatment regimens because of an inability to disrupt covalently closed circular DNA and an inadequate host immune response. Therefore, new antiviral agents ar...

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Veröffentlicht in:	The Lancet infectious diseases 2016-02, Vol.16 (2), p.e10-e21
Hauptverfasser:	Brahmania, Mayur, MD, Feld, Jordan, MD, Arif, Ambreen, MD, Janssen, Harry L A, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral agents Antiviral Agents - therapeutic use Deoxyribonucleic acid DNA Genomes Heparan sulfate Hepatitis Hepatitis B Hepatitis B virus - drug effects Hepatitis B, Chronic - drug therapy Humans Immune response Immune system Infectious Disease Infectious diseases Inflammation Interferon Liver cancer Liver cirrhosis Liver diseases Mutation Polypeptides Proteins Virus Replication - drug effects
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