Synthesis, Conformational Properties, and Immunogenicity of a Cyclic Template-Bound Peptide Mimetic Containing an NPNA Motif from the Circumsporozoite Protein of Plasmodium falciparum

The immunodominant central portion of the circumsporozoite (CS) surface protein of the malaria parasite Plasmodium falciparum contains a tetrapeptide motif, Asn-Pro-Asn-Ala (NPNA), tandemly repeated almost 40 times. The three-dimensional structure of the CS protein, including the central repeat regi...

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Veröffentlicht in:	Journal of the American Chemical Society 1998-08, Vol.120 (30), p.7439-7449
Hauptverfasser:	BISANG, Christian, JIANG, Luyong, FREUND, Ernst, EMERY, Fabienne, BAUCH, Christian, MATILE, Hugues, PLUSCHKE, Gerd, ROBINSON, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	circumsporozoite protein NPNA motif Plasmodium falciparum
Online-Zugang:	Volltext
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