Inhibitor of DNA binding 4 functions as a tumor suppressor and is targetable by 5-aza-2′-deoxycytosine with potential therapeutic significance in Burkitt's lymphoma

Epigenetic gene silencing due to promoter methylation is observed in human neoplasia, including lymphoma and certain cancer types. One important target for gene methylation analysis in non-Hodgkin lymphoma (NHL) is inhibitor of DNA binding 4 (ID4). The present study aimed to investigate the gene met...

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Veröffentlicht in:	Molecular medicine reports 2016-02, Vol.13 (2), p.1269-1274
Hauptverfasser:	GAO, XIAN-ZHENG, ZHAO, WU-GAN, WANG, GUAN-NAN, CUI, MEI-YING, ZHANG, YANG-RUI, LI, WEN-CAI
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2′-deoxycytosine Angiogenesis Apoptosis Apoptosis - genetics Azacitidine - administration & dosage Azacitidine - analogs & derivatives Breast cancer Burkitt Lymphoma - genetics Burkitt Lymphoma - pathology Burkitt's lymphoma Cancer Cancer therapies Cell cycle Cell Cycle - genetics Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Deoxyribonucleic acid Development and progression DNA DNA methylation DNA Methylation - genetics Epigenetics Flow cytometry Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene flow Gene Silencing Genes Genes, Tumor Suppressor Genetic aspects Health aspects Humans Inhibitor of Differentiation Proteins - biosynthesis Inhibitor of Differentiation Proteins - genetics inhibitor of DNA binding 4 Leukemia Lymphoma Multivariate analysis Peroxidase Polyclonal antibodies Polymerase chain reaction Promoter Regions, Genetic Properties Protein expression Proteins Raji cells Streptavidin Studies Transcription factors Tumor suppressor genes Tumors
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