Risk of severe cardiotoxicity following treatment with trastuzumab: a meta-analysis of randomized and cohort studies of 29,000 women with breast cancer

Trastuzumab prolongs survival in women with HER2-positive breast cancer, but may increase the risk of heart disease. The occurrence of severe cardiotoxicity, however, is not defined in real-life settings. We performed a meta-analysis of clinical trials and cohort studies to estimate the frequency of...

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Veröffentlicht in:	Internal and emergency medicine 2016-02, Vol.11 (1), p.123-140
Hauptverfasser:	Mantarro, Stefania, Rossi, Marta, Bonifazi, Martina, D’Amico, Roberto, Blandizzi, Corrado, La Vecchia, Carlo, Negri, Eva, Moja, Lorenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - adverse effects Breast Neoplasms - complications Breast Neoplasms - drug therapy Cardiotoxicity Cardiovascular Diseases - epidemiology Female Hta-Original Humans Internal Medicine Medicine Medicine & Public Health Trastuzumab - adverse effects
Online-Zugang:	Volltext
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