Differentiation of malignant from benign soft tissue tumours: use of additive qualitative and quantitative diffusion-weighted MR imaging to standard MR imaging at 3.0 T
Objectives To determine the added value of diffusion-weighted imaging (DWI) to standard magnetic resonance imaging (MRI) to differentiate malignant from benign soft tissue tumours at 3.0 T. Methods 3.0 T MR images including DWI in 63 patients who underwent surgery for soft tissue tumours were retros...
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| Veröffentlicht in: | European radiology 2016-03, Vol.26 (3), p.743-754 |
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| creator | Lee, So-Yeon Jee, Won-Hee Jung, Joon-Yong Park, Michael Y. Kim, Sun-Ki Jung, Chan-Kwon Chung, Yang-Guk |
| description | Objectives
To determine the added value of diffusion-weighted imaging (DWI) to standard magnetic resonance imaging (MRI) to differentiate malignant from benign soft tissue tumours at 3.0 T.
Methods
3.0 T MR images including DWI in 63 patients who underwent surgery for soft tissue tumours were retrospectively analyzed. Two readers independently interpreted MRI for the presence of malignancy in two steps: standard MRI alone, standard MRI and DWI with qualitative and quantitative analysis combined.
Results
There were 34 malignant and 29 non-malignant soft tissue tumours. In qualitative analysis, hyperintensity relative to skeletal muscle was more frequent in malignant than benign tumours on DWI (
P
=0.003). In quantitative analysis, ADCs of malignant tumours were significantly lower than those of non-malignant tumours (
P
≤0.002): 759±385 vs. 1188±423 μm
2
/sec minimum ADC value, 941±440 vs. 1310±440 μm
2
/sec average ADC value. The mean sensitivity, specificity and accuracy of both readers were 96 %, 72 %, and 85 % on standard MRI alone and 97 %, 90 %, and 94 % on standard MRI with DWI.
Conclusions
The addition of DWI to standard MRI improves the diagnostic accuracy for differentiation of malignant from benign soft tissue tumours at 3.0 T.
Key Points
•
DWI has added value for differentiating malignant from benign soft tissue tumours.
•
Addition of DWI to standard MRI at 3.0 T improves the diagnostic accuracy.
•
Measurements of both ADC
min
within solid portion and ADC
av
are helpful. |
| doi_str_mv | 10.1007/s00330-015-3878-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1764699325</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1764699325</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-d69aca5b09d04f92fdc12fce78875f41880bfa6d82e24a79905c3402f779f3c23</originalsourceid><addsrcrecordid>eNp1kdtuFSEUhonR2G31AbwxJN54M-3iMAN4Z2o9JDVNTL2esAcYafZAy0HbN_IxZXdvTTXpFbD4_n_B-hF6SeCIAIjjDMAYdED6jkkhu5tHaEU4ox0ByR-jFSgmO6EUP0DPcr4EAEW4eIoO6AAShBpW6Nd775xNNhSvi48BR4cXvfFz0KFgl-KC1za0I87RFVx8ztXiUpdYU36La7ZbhTbGF__D4uvatEXf7XUw23Nz3hdMa1Vza9L9tH7-XqzBX75iv-jZhxmXiHNpGp3-KeuC2RHgi-foidObbF_s10P07cPpxcmn7uz84-eTd2fdxDktnRmUnnS_BmWAO0WdmQh1kxVSit5xIiWsnR6MpJZy3WYD_cQ4UCeEcmyi7BC92flepXhdbS7j4vNkNxsdbKx5JGLgg1KM9g19_R962aYS2uvuKBg4IaJRZEdNKeacrBuvUvtcuh0JjNsYx12MY4tx3MY43jTNq71zXS_W_FX8ya0BdAfkdhVmm-61ftD1N4QRqtc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1764064117</pqid></control><display><type>article</type><title>Differentiation of malignant from benign soft tissue tumours: use of additive qualitative and quantitative diffusion-weighted MR imaging to standard MR imaging at 3.0 T</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Lee, So-Yeon ; Jee, Won-Hee ; Jung, Joon-Yong ; Park, Michael Y. ; Kim, Sun-Ki ; Jung, Chan-Kwon ; Chung, Yang-Guk</creator><creatorcontrib>Lee, So-Yeon ; Jee, Won-Hee ; Jung, Joon-Yong ; Park, Michael Y. ; Kim, Sun-Ki ; Jung, Chan-Kwon ; Chung, Yang-Guk</creatorcontrib><description>Objectives
To determine the added value of diffusion-weighted imaging (DWI) to standard magnetic resonance imaging (MRI) to differentiate malignant from benign soft tissue tumours at 3.0 T.
Methods
3.0 T MR images including DWI in 63 patients who underwent surgery for soft tissue tumours were retrospectively analyzed. Two readers independently interpreted MRI for the presence of malignancy in two steps: standard MRI alone, standard MRI and DWI with qualitative and quantitative analysis combined.
Results
There were 34 malignant and 29 non-malignant soft tissue tumours. In qualitative analysis, hyperintensity relative to skeletal muscle was more frequent in malignant than benign tumours on DWI (
P
=0.003). In quantitative analysis, ADCs of malignant tumours were significantly lower than those of non-malignant tumours (
P
≤0.002): 759±385 vs. 1188±423 μm
2
/sec minimum ADC value, 941±440 vs. 1310±440 μm
2
/sec average ADC value. The mean sensitivity, specificity and accuracy of both readers were 96 %, 72 %, and 85 % on standard MRI alone and 97 %, 90 %, and 94 % on standard MRI with DWI.
Conclusions
The addition of DWI to standard MRI improves the diagnostic accuracy for differentiation of malignant from benign soft tissue tumours at 3.0 T.
Key Points
•
DWI has added value for differentiating malignant from benign soft tissue tumours.
•
Addition of DWI to standard MRI at 3.0 T improves the diagnostic accuracy.
•
Measurements of both ADC
min
within solid portion and ADC
av
are helpful.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-015-3878-x</identifier><identifier>PMID: 26080796</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Accuracy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bone surgery ; Cysts ; Diagnosis, Differential ; Diagnostic Radiology ; Diffusion Magnetic Resonance Imaging - methods ; Female ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical schools ; Medicine ; Medicine & Public Health ; Middle Aged ; Musculoskeletal ; Neuroradiology ; Observer Variation ; Quantitative analysis ; Radiology ; Retrospective Studies ; Sensitivity and Specificity ; Soft Tissue Neoplasms - pathology ; Tumors ; Ultrasound ; Young Adult</subject><ispartof>European radiology, 2016-03, Vol.26 (3), p.743-754</ispartof><rights>European Society of Radiology 2015</rights><rights>European Society of Radiology 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-d69aca5b09d04f92fdc12fce78875f41880bfa6d82e24a79905c3402f779f3c23</citedby><cites>FETCH-LOGICAL-c442t-d69aca5b09d04f92fdc12fce78875f41880bfa6d82e24a79905c3402f779f3c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-015-3878-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-015-3878-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26080796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, So-Yeon</creatorcontrib><creatorcontrib>Jee, Won-Hee</creatorcontrib><creatorcontrib>Jung, Joon-Yong</creatorcontrib><creatorcontrib>Park, Michael Y.</creatorcontrib><creatorcontrib>Kim, Sun-Ki</creatorcontrib><creatorcontrib>Jung, Chan-Kwon</creatorcontrib><creatorcontrib>Chung, Yang-Guk</creatorcontrib><title>Differentiation of malignant from benign soft tissue tumours: use of additive qualitative and quantitative diffusion-weighted MR imaging to standard MR imaging at 3.0 T</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To determine the added value of diffusion-weighted imaging (DWI) to standard magnetic resonance imaging (MRI) to differentiate malignant from benign soft tissue tumours at 3.0 T.
Methods
3.0 T MR images including DWI in 63 patients who underwent surgery for soft tissue tumours were retrospectively analyzed. Two readers independently interpreted MRI for the presence of malignancy in two steps: standard MRI alone, standard MRI and DWI with qualitative and quantitative analysis combined.
Results
There were 34 malignant and 29 non-malignant soft tissue tumours. In qualitative analysis, hyperintensity relative to skeletal muscle was more frequent in malignant than benign tumours on DWI (
P
=0.003). In quantitative analysis, ADCs of malignant tumours were significantly lower than those of non-malignant tumours (
P
≤0.002): 759±385 vs. 1188±423 μm
2
/sec minimum ADC value, 941±440 vs. 1310±440 μm
2
/sec average ADC value. The mean sensitivity, specificity and accuracy of both readers were 96 %, 72 %, and 85 % on standard MRI alone and 97 %, 90 %, and 94 % on standard MRI with DWI.
Conclusions
The addition of DWI to standard MRI improves the diagnostic accuracy for differentiation of malignant from benign soft tissue tumours at 3.0 T.
Key Points
•
DWI has added value for differentiating malignant from benign soft tissue tumours.
•
Addition of DWI to standard MRI at 3.0 T improves the diagnostic accuracy.
•
Measurements of both ADC
min
within solid portion and ADC
av
are helpful.</description><subject>Accuracy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone surgery</subject><subject>Cysts</subject><subject>Diagnosis, Differential</subject><subject>Diagnostic Radiology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Musculoskeletal</subject><subject>Neuroradiology</subject><subject>Observer Variation</subject><subject>Quantitative analysis</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Tumors</subject><subject>Ultrasound</subject><subject>Young Adult</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kdtuFSEUhonR2G31AbwxJN54M-3iMAN4Z2o9JDVNTL2esAcYafZAy0HbN_IxZXdvTTXpFbD4_n_B-hF6SeCIAIjjDMAYdED6jkkhu5tHaEU4ox0ByR-jFSgmO6EUP0DPcr4EAEW4eIoO6AAShBpW6Nd775xNNhSvi48BR4cXvfFz0KFgl-KC1za0I87RFVx8ztXiUpdYU36La7ZbhTbGF__D4uvatEXf7XUw23Nz3hdMa1Vza9L9tH7-XqzBX75iv-jZhxmXiHNpGp3-KeuC2RHgi-foidObbF_s10P07cPpxcmn7uz84-eTd2fdxDktnRmUnnS_BmWAO0WdmQh1kxVSit5xIiWsnR6MpJZy3WYD_cQ4UCeEcmyi7BC92flepXhdbS7j4vNkNxsdbKx5JGLgg1KM9g19_R962aYS2uvuKBg4IaJRZEdNKeacrBuvUvtcuh0JjNsYx12MY4tx3MY43jTNq71zXS_W_FX8ya0BdAfkdhVmm-61ftD1N4QRqtc</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Lee, So-Yeon</creator><creator>Jee, Won-Hee</creator><creator>Jung, Joon-Yong</creator><creator>Park, Michael Y.</creator><creator>Kim, Sun-Ki</creator><creator>Jung, Chan-Kwon</creator><creator>Chung, Yang-Guk</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>Differentiation of malignant from benign soft tissue tumours: use of additive qualitative and quantitative diffusion-weighted MR imaging to standard MR imaging at 3.0 T</title><author>Lee, So-Yeon ; Jee, Won-Hee ; Jung, Joon-Yong ; Park, Michael Y. ; Kim, Sun-Ki ; Jung, Chan-Kwon ; Chung, Yang-Guk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-d69aca5b09d04f92fdc12fce78875f41880bfa6d82e24a79905c3402f779f3c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Accuracy</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone surgery</topic><topic>Cysts</topic><topic>Diagnosis, Differential</topic><topic>Diagnostic Radiology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Musculoskeletal</topic><topic>Neuroradiology</topic><topic>Observer Variation</topic><topic>Quantitative analysis</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Soft Tissue Neoplasms - pathology</topic><topic>Tumors</topic><topic>Ultrasound</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, So-Yeon</creatorcontrib><creatorcontrib>Jee, Won-Hee</creatorcontrib><creatorcontrib>Jung, Joon-Yong</creatorcontrib><creatorcontrib>Park, Michael Y.</creatorcontrib><creatorcontrib>Kim, Sun-Ki</creatorcontrib><creatorcontrib>Jung, Chan-Kwon</creatorcontrib><creatorcontrib>Chung, Yang-Guk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, So-Yeon</au><au>Jee, Won-Hee</au><au>Jung, Joon-Yong</au><au>Park, Michael Y.</au><au>Kim, Sun-Ki</au><au>Jung, Chan-Kwon</au><au>Chung, Yang-Guk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiation of malignant from benign soft tissue tumours: use of additive qualitative and quantitative diffusion-weighted MR imaging to standard MR imaging at 3.0 T</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>26</volume><issue>3</issue><spage>743</spage><epage>754</epage><pages>743-754</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To determine the added value of diffusion-weighted imaging (DWI) to standard magnetic resonance imaging (MRI) to differentiate malignant from benign soft tissue tumours at 3.0 T.
Methods
3.0 T MR images including DWI in 63 patients who underwent surgery for soft tissue tumours were retrospectively analyzed. Two readers independently interpreted MRI for the presence of malignancy in two steps: standard MRI alone, standard MRI and DWI with qualitative and quantitative analysis combined.
Results
There were 34 malignant and 29 non-malignant soft tissue tumours. In qualitative analysis, hyperintensity relative to skeletal muscle was more frequent in malignant than benign tumours on DWI (
P
=0.003). In quantitative analysis, ADCs of malignant tumours were significantly lower than those of non-malignant tumours (
P
≤0.002): 759±385 vs. 1188±423 μm
2
/sec minimum ADC value, 941±440 vs. 1310±440 μm
2
/sec average ADC value. The mean sensitivity, specificity and accuracy of both readers were 96 %, 72 %, and 85 % on standard MRI alone and 97 %, 90 %, and 94 % on standard MRI with DWI.
Conclusions
The addition of DWI to standard MRI improves the diagnostic accuracy for differentiation of malignant from benign soft tissue tumours at 3.0 T.
Key Points
•
DWI has added value for differentiating malignant from benign soft tissue tumours.
•
Addition of DWI to standard MRI at 3.0 T improves the diagnostic accuracy.
•
Measurements of both ADC
min
within solid portion and ADC
av
are helpful.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26080796</pmid><doi>10.1007/s00330-015-3878-x</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2016-03, Vol.26 (3), p.743-754 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1764699325 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Accuracy Adolescent Adult Aged Aged, 80 and over Bone surgery Cysts Diagnosis, Differential Diagnostic Radiology Diffusion Magnetic Resonance Imaging - methods Female Humans Imaging Internal Medicine Interventional Radiology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical schools Medicine Medicine & Public Health Middle Aged Musculoskeletal Neuroradiology Observer Variation Quantitative analysis Radiology Retrospective Studies Sensitivity and Specificity Soft Tissue Neoplasms - pathology Tumors Ultrasound Young Adult |
| title | Differentiation of malignant from benign soft tissue tumours: use of additive qualitative and quantitative diffusion-weighted MR imaging to standard MR imaging at 3.0 T |
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