Expression of DNA double-strand break repair proteins predicts the response and prognosis of colorectal cancer patients undergoing oxaliplatin-based chemotherapy

DNA intrastrand cross-linking agents such as oxaliplatin induce DNA double-strand breaks (DSBs) during DNA repair and replication. In the present study, we hypothesized that DNA intrastrand cross-linking agents may significantly benefit colorectal cancer patients with deficiencies in DSB repair. Sev...

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Veröffentlicht in:	Oncology reports 2016-03, Vol.35 (3), p.1349-1355
Hauptverfasser:	IHARA, KEISUKE, YAMAGUCHI, SATORU, UENO, NOZOMI, TANI, YUKIKO, SHIDA, YOSUKE, OGATA, HIDEO, DOMEKI, YASUSHI, OKAMOTO, KENTARO, NAKAJIMA, MASANOBU, SASAKI, KINRO, TSUCHIOKA, TAKASHI, MITOMI, HIROYUKI, KATO, HIROYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Biomarkers Cancer therapies Chemotherapy Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Deoxyribonucleic acid Development and progression Disease-Free Survival DNA DNA Breaks, Double-Stranded - drug effects DNA damage DNA Damage - genetics DNA Repair - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Drug metabolism DSB repair protein expression pattern Female Females Gender Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Growth factors Health aspects Histology Humans immunohistochemistry Male Medical prognosis Metastasis Middle Aged MRE11 MRE11 Homologue Protein Multivariate analysis Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Organoplatinum Compounds - administration & dosage Oxaliplatin Patients Prognosis Protein expression Proteins RAD51 Rad51 Recombinase - biosynthesis Rad51 Recombinase - genetics Rodents
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