IL-6 mediates the signal pathway of JAK-STAT3-VEGF-C promoting growth, invasion and lymphangiogenesis in gastric cancer

Gastric cancer shows the highest invasive and metastasis features, especially lymph metastasis, which is closely associated with poor prognosis of gastric cancer. Although there is evidence that interleukin-6 (IL-6) can promote gastric cancer progression, the underlying specific mechanisms and the m...

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Veröffentlicht in:	Oncology reports 2016-03, Vol.35 (3), p.1787-1795
Hauptverfasser:	ZHAO, GUIBIN, ZHU, GUANGWEI, HUANG, YONGJIAN, ZHENG, WEI, HUA, JIN, YANG, SHUGANG, ZHUANG, JINFU, YE, JIANXIN
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cell culture Cell growth Cell Line, Tumor Cell Proliferation - genetics Cellular signal transduction Cytokine Receptor gp130 - biosynthesis Cytokine Receptor gp130 - genetics Development and progression Fluorides Gastric cancer gastric cancer cell Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Innovations interleukin-6 Interleukin-6 - biosynthesis Interleukin-6 - genetics Interleukins invasion JAK-STAT3 Janus Kinases - genetics Kinases Lung cancer Lymphangiogenesis - genetics Lymphatic Metastasis Lymphatic system Medical prognosis Metastasis Molecular targeted therapy Neoplasm Invasiveness - genetics proliferation Protein expression Proteins Signal Transduction STAT3 Transcription Factor - biosynthesis STAT3 Transcription Factor - genetics Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - pathology Studies Vascular endothelial growth factor Vascular Endothelial Growth Factor C - biosynthesis Vascular Endothelial Growth Factor C - genetics VEGF-C
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