MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1

Wnt/β-catenin signaling pathway influences embryonic development, cell polarity and adhesion, apoptosis and tumorigenesis. MicroRNAs (miRNAs) function as important regulators of the tumorigenesis and metastasis. In the present study, we aimed to find novel targets and mechanisms of microRNA-148a (mi...

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Veröffentlicht in:	Oncology reports 2016-03, Vol.35 (3), p.1425-1432
Hauptverfasser:	JIANG, QIAN, HE, MIAO, MA, MENG-TAO, WU, HUI-ZHE, YU, ZHAO-JIN, GUAN, SHU, JIANG, LONG-YANG, WANG, YAN, ZHENG, DA-DI, JIN, FENG, WEI, MIN-JIE
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis beta Catenin - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cell growth Cell migration Cell Movement - genetics Development and progression Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genetic regulation Health aspects Humans invasion Kinases MCF-7 Cells Metastasis MicroRNA MicroRNAs MicroRNAs - genetics migration miR-148a Neoplasm Invasiveness - genetics Proteins RNA, Messenger - biosynthesis Rodents Studies Tumorigenesis Tumors Wnt Signaling Pathway - genetics WNT-1 Wnt/β-catenin signaling pathway Wnt1 Protein - genetics Wnt1 Protein - metabolism
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