Does Sarcopenia Impact Complications and Overall Survival in Patients Undergoing Radical Nephrectomy for Stage III and IV Kidney Cancer?
To investigate the association of sarcopenia (muscle mass wasting) with complications and survival in patients undergoing radical nephrectomy for advanced kidney cancer. We identified 137 patients with stage III and IV kidney cancer who underwent radical nephrectomy between 2008 and 2012. Preoperati...
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| Veröffentlicht in: | Journal of endourology 2016-02, Vol.30 (2), p.229-236 |
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| creator | Peyton, Charles C Heavner, Matthew G Rague, James T Krane, L Spencer Hemal, Ashok K |
| description | To investigate the association of sarcopenia (muscle mass wasting) with complications and survival in patients undergoing radical nephrectomy for advanced kidney cancer.
We identified 137 patients with stage III and IV kidney cancer who underwent radical nephrectomy between 2008 and 2012. Preoperative cross-sectional imaging was used to measure total psoas area (TPA) at the level of L3 and controlled for height (m(2)). Sarcopenia was identified as TPA in the lowest gender-specific quartile. Patient characteristics and postoperative complications were compared between sarcopenic and nonsarcopenic patients. Kaplan-Meier survival curve estimates were generated for overall and gender-specific survival.
Preoperative cross-sectional imaging was available for 128 patients (93%, 85 men and 43 women). Mean TPA for men was 5.49 cm(2)/m(2) versus 4.27 cm(2)/m(2) for women (P |
| doi_str_mv | 10.1089/end.2015.0492 |
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We identified 137 patients with stage III and IV kidney cancer who underwent radical nephrectomy between 2008 and 2012. Preoperative cross-sectional imaging was used to measure total psoas area (TPA) at the level of L3 and controlled for height (m(2)). Sarcopenia was identified as TPA in the lowest gender-specific quartile. Patient characteristics and postoperative complications were compared between sarcopenic and nonsarcopenic patients. Kaplan-Meier survival curve estimates were generated for overall and gender-specific survival.
Preoperative cross-sectional imaging was available for 128 patients (93%, 85 men and 43 women). Mean TPA for men was 5.49 cm(2)/m(2) versus 4.27 cm(2)/m(2) for women (P < 0.05). Sarcopenia was associated with risk of Clavien grade III or higher complication (P = 0.03) and node-positive disease (P = 0.01). Median follow-up was 48.3 months. Kaplan-Meier estimates of overall and gender-specific survival were similar between sarcopenic and nonsarcopenic patients.
Sarcopenia appears to be associated with risk of major complication after radical nephrectomy for advanced kidney cancer. It was not related to overall survival, however. This preoperative imaging tool may be helpful in preoperative counseling and preparation.</description><identifier>ISSN: 0892-7790</identifier><identifier>EISSN: 1557-900X</identifier><identifier>DOI: 10.1089/end.2015.0492</identifier><identifier>PMID: 26418428</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Renal Cell - epidemiology ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - surgery ; Comorbidity ; Female ; Humans ; Kaplan-Meier Estimate ; Kidney Neoplasms - epidemiology ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Male ; Middle Aged ; Neoplasm Staging ; Nephrectomy ; Organ Size ; Postoperative Complications - epidemiology ; Preoperative Period ; Psoas Muscles - diagnostic imaging ; Radiography ; Retrospective Studies ; Risk Factors ; Sarcopenia - diagnostic imaging ; Sarcopenia - epidemiology ; Survival Rate</subject><ispartof>Journal of endourology, 2016-02, Vol.30 (2), p.229-236</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-400ba8ce41173e057b59ac0beffa11aa87adf388d9da797311035b6a846c05e13</citedby><cites>FETCH-LOGICAL-c359t-400ba8ce41173e057b59ac0beffa11aa87adf388d9da797311035b6a846c05e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26418428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peyton, Charles C</creatorcontrib><creatorcontrib>Heavner, Matthew G</creatorcontrib><creatorcontrib>Rague, James T</creatorcontrib><creatorcontrib>Krane, L Spencer</creatorcontrib><creatorcontrib>Hemal, Ashok K</creatorcontrib><title>Does Sarcopenia Impact Complications and Overall Survival in Patients Undergoing Radical Nephrectomy for Stage III and IV Kidney Cancer?</title><title>Journal of endourology</title><addtitle>J Endourol</addtitle><description>To investigate the association of sarcopenia (muscle mass wasting) with complications and survival in patients undergoing radical nephrectomy for advanced kidney cancer.
We identified 137 patients with stage III and IV kidney cancer who underwent radical nephrectomy between 2008 and 2012. Preoperative cross-sectional imaging was used to measure total psoas area (TPA) at the level of L3 and controlled for height (m(2)). Sarcopenia was identified as TPA in the lowest gender-specific quartile. Patient characteristics and postoperative complications were compared between sarcopenic and nonsarcopenic patients. Kaplan-Meier survival curve estimates were generated for overall and gender-specific survival.
Preoperative cross-sectional imaging was available for 128 patients (93%, 85 men and 43 women). Mean TPA for men was 5.49 cm(2)/m(2) versus 4.27 cm(2)/m(2) for women (P < 0.05). Sarcopenia was associated with risk of Clavien grade III or higher complication (P = 0.03) and node-positive disease (P = 0.01). Median follow-up was 48.3 months. Kaplan-Meier estimates of overall and gender-specific survival were similar between sarcopenic and nonsarcopenic patients.
Sarcopenia appears to be associated with risk of major complication after radical nephrectomy for advanced kidney cancer. It was not related to overall survival, however. This preoperative imaging tool may be helpful in preoperative counseling and preparation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Renal Cell - epidemiology</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney Neoplasms - epidemiology</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Nephrectomy</subject><subject>Organ Size</subject><subject>Postoperative Complications - epidemiology</subject><subject>Preoperative Period</subject><subject>Psoas Muscles - diagnostic imaging</subject><subject>Radiography</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sarcopenia - diagnostic imaging</subject><subject>Sarcopenia - epidemiology</subject><subject>Survival Rate</subject><issn>0892-7790</issn><issn>1557-900X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFP3DAQRi3Uqmxpj1yRj71ka8dJbJ-qaqFtBALULRW3aGJPFqPEDnZ2pf0H_dnNFuhpDt-bd3iEnHK25Ezpz-jtMme8XLJC50dkwctSZpqx-zdkMe95JqVmx-R9So-McVFx8Y4c51XBVZGrBflzHjDRNUQTRvQOaD2MYCa6CsPYOwOTCz5R8Jbe7DBC39P1Nu7cDnrqPL2dd_RTonfeYtwE5zf0J9j5r6fXOD5ENFMY9rQLka4n2CCt6_qfrf5NL531uKcr8Abjlw_kbQd9wo8v94Tcfbv4tfqRXd18r1dfrzIjSj1lBWMtKIMF51IgK2VbajCsxa4DzgGUBNsJpay2ILUUnDNRthWoojKsRC5OyKdn7xjD0xbT1AwuGex78Bi2qeGyKiotldQzmj2jJoaUInbNGN0Acd9w1hziN3P85hC_OcSf-bMX9bYd0P6nX2uLv1yKgP4</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Peyton, Charles C</creator><creator>Heavner, Matthew G</creator><creator>Rague, James T</creator><creator>Krane, L Spencer</creator><creator>Hemal, Ashok K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201602</creationdate><title>Does Sarcopenia Impact Complications and Overall Survival in Patients Undergoing Radical Nephrectomy for Stage III and IV Kidney Cancer?</title><author>Peyton, Charles C ; Heavner, Matthew G ; Rague, James T ; Krane, L Spencer ; Hemal, Ashok K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-400ba8ce41173e057b59ac0beffa11aa87adf388d9da797311035b6a846c05e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Renal Cell - epidemiology</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Kidney Neoplasms - epidemiology</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Nephrectomy</topic><topic>Organ Size</topic><topic>Postoperative Complications - epidemiology</topic><topic>Preoperative Period</topic><topic>Psoas Muscles - diagnostic imaging</topic><topic>Radiography</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sarcopenia - diagnostic imaging</topic><topic>Sarcopenia - epidemiology</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peyton, Charles C</creatorcontrib><creatorcontrib>Heavner, Matthew G</creatorcontrib><creatorcontrib>Rague, James T</creatorcontrib><creatorcontrib>Krane, L Spencer</creatorcontrib><creatorcontrib>Hemal, Ashok K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endourology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peyton, Charles C</au><au>Heavner, Matthew G</au><au>Rague, James T</au><au>Krane, L Spencer</au><au>Hemal, Ashok K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Sarcopenia Impact Complications and Overall Survival in Patients Undergoing Radical Nephrectomy for Stage III and IV Kidney Cancer?</atitle><jtitle>Journal of endourology</jtitle><addtitle>J Endourol</addtitle><date>2016-02</date><risdate>2016</risdate><volume>30</volume><issue>2</issue><spage>229</spage><epage>236</epage><pages>229-236</pages><issn>0892-7790</issn><eissn>1557-900X</eissn><abstract>To investigate the association of sarcopenia (muscle mass wasting) with complications and survival in patients undergoing radical nephrectomy for advanced kidney cancer.
We identified 137 patients with stage III and IV kidney cancer who underwent radical nephrectomy between 2008 and 2012. Preoperative cross-sectional imaging was used to measure total psoas area (TPA) at the level of L3 and controlled for height (m(2)). Sarcopenia was identified as TPA in the lowest gender-specific quartile. Patient characteristics and postoperative complications were compared between sarcopenic and nonsarcopenic patients. Kaplan-Meier survival curve estimates were generated for overall and gender-specific survival.
Preoperative cross-sectional imaging was available for 128 patients (93%, 85 men and 43 women). Mean TPA for men was 5.49 cm(2)/m(2) versus 4.27 cm(2)/m(2) for women (P < 0.05). Sarcopenia was associated with risk of Clavien grade III or higher complication (P = 0.03) and node-positive disease (P = 0.01). Median follow-up was 48.3 months. Kaplan-Meier estimates of overall and gender-specific survival were similar between sarcopenic and nonsarcopenic patients.
Sarcopenia appears to be associated with risk of major complication after radical nephrectomy for advanced kidney cancer. It was not related to overall survival, however. This preoperative imaging tool may be helpful in preoperative counseling and preparation.</abstract><cop>United States</cop><pmid>26418428</pmid><doi>10.1089/end.2015.0492</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Carcinoma, Renal Cell - epidemiology Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - surgery Comorbidity Female Humans Kaplan-Meier Estimate Kidney Neoplasms - epidemiology Kidney Neoplasms - pathology Kidney Neoplasms - surgery Male Middle Aged Neoplasm Staging Nephrectomy Organ Size Postoperative Complications - epidemiology Preoperative Period Psoas Muscles - diagnostic imaging Radiography Retrospective Studies Risk Factors Sarcopenia - diagnostic imaging Sarcopenia - epidemiology Survival Rate |
| title | Does Sarcopenia Impact Complications and Overall Survival in Patients Undergoing Radical Nephrectomy for Stage III and IV Kidney Cancer? |
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