A Rac1/Phosphatidylinositol 3-Kinase/Akt3 Anti-apoptotic Pathway, Triggered by AlsinLF, the Product of the ALS2 Gene, Antagonizes Cu/Zn-superoxide Dismutase (SOD1) Mutant-induced Motoneuronal Cell Death

AlsinLF, the product of the ALS2 gene, inhibits Cu/Zn-superoxide dismutase (SOD1) mutant-induced neurotoxicity via its Rho guanine nucleotide-exchanging factor domain. We here identified Rac1, a Rho family small GTPase, as a target for the Rho guanine nucleotide-exchanging factor activity of alsinLF...

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Veröffentlicht in:	The Journal of biological chemistry 2005-02, Vol.280 (6), p.4532-4543
Hauptverfasser:	Kanekura, Kohsuke, Hashimoto, Yuichi, Kita, Yoshiko, Sasabe, Jumpei, Aiso, Sadakazu, Nishimoto, Ikuo, Matsuoka, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Apoptosis Cell Death Cell Line Cells, Cultured CHO Cells Cricetinae DNA - metabolism Down-Regulation Enzyme Inhibitors - pharmacology Escherichia coli - metabolism Glutathione - chemistry Glutathione Transferase - metabolism GTP Phosphohydrolases - metabolism Guanine - chemistry Guanine Nucleotide Exchange Factors - metabolism Humans Immunoblotting Mice Models, Biological Motor Neurons - metabolism Mutation Neurons - metabolism Phosphatidylinositol 3-Kinases - metabolism Plasmids - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt rac1 GTP-Binding Protein - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - metabolism Sepharose - chemistry Superoxide Dismutase - genetics Time Factors Transfection Wortmannin
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