Cadmium-inducible Expression of the Yeast GSH1 Gene Requires a Functional Sulfur-Amino Acid Regulatory Network

Glutathione (γ-l-glutamyl-l-cysteinylglycine) is an important antioxidant molecule, helping to buffer the cell against free radicals and toxic electrophiles. Expression of the yeastGSH1 gene, encoding the first enzyme involved in glutathione biosynthesis, γ-glutamylcysteine synthetase, is regulated...

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Veröffentlicht in:	The Journal of biological chemistry 2000-10, Vol.275 (42), p.32611-32616
Hauptverfasser:	Dormer, Ulla H., Westwater, John, McLaren, Niall F., Kent, Nicholas A., Mellor, Jane, Jamieson, Derek J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Basic Helix-Loop-Helix Leucine Zipper Transcription Factors beta-Galactosidase - biosynthesis beta-Galactosidase - genetics Cadmium - pharmacology Cbf1 protein Chromatin - genetics Chromatin - ultrastructure DNA-Binding Proteins - genetics Drug Resistance, Microbial Fungal Proteins - genetics g-Glutamylcysteine synthase Gene Expression Regulation, Fungal - drug effects Genotype Glutamate-Cysteine Ligase - genetics GSH1 gene Met-31 protein Met-32 protein Met-4 protein Molecular Sequence Data Oligodeoxyribonucleotides Promoter Regions, Genetic RNA-Binding Proteins - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae Proteins Sequence Deletion
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