Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression

Polygenic factors play important roles in animal models of substance abuse and susceptibility to dopaminergic neurodegeneration. Genetic factors are also likely to contribute to the etiology of human drug abuse disorders, and may alter human vulnerabilities to Parkinsonian neurodegeneration. The dop...

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Veröffentlicht in:	Brain research. Molecular brain research. 1999-11, Vol.73 (1), p.37-49
Hauptverfasser:	Donovan, David M, Miner, Lucinda L, Perry, Michael P, Revay, Randal S, Sharpe, Lawrence G, Przedborski, Serge, Kostic, Vladimir, Philpot, Rex M, Kirstein, Cheryl L, Rothman, Richard B, Schindler, Charles W, Uhl, George R
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage 3,4-Dihydroxyphenylacetic Acid - metabolism Animals Behavior, Animal - physiology Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Chromatography, High Pressure Liquid Cocaine Cocaine - pharmacology Conditioned place preference Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins Dopamine transporter Drug addictions Drug reward Female Gene Expression Regulation Genetic Variation Homovanillic Acid - metabolism Hydroxyindoleacetic Acid - metabolism Male Medical sciences Membrane Glycoproteins Membrane Transport Proteins Mice Mice, Inbred Strains Mice, Transgenic Motor Activity - drug effects Motor Activity - genetics MPTP MPTP Poisoning - genetics MPTP Poisoning - metabolism Nerve Tissue Proteins Promoter Regions, Genetic - genetics Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Reward Serotonin - metabolism Substantia Nigra - cytology Substantia Nigra - drug effects Substantia Nigra - enzymology Toxicology Transgenes - genetics Transgenic mice Tyrosine 3-Monooxygenase - genetics Tyrosine 3-Monooxygenase - metabolism
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