Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls

Recent studies suggest that melatonin 1b (Mel 1b) receptor, as well as melatonin 1a (Mel 1a) receptor, is involved in the modulation of circadian rhythms in mammals. Mutational analysis was performed in the entire coding region of the human Mel 1b receptor gene using genomic DNA from sleep disorder...

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Veröffentlicht in:	Neuroscience letters 2000-02, Vol.280 (1), p.29-32
Hauptverfasser:	Ebisawa, Takashi, Uchiyama, Makoto, Kajimura, Naofumi, Kamei, Yuichi, Shibui, Kayo, Kim, Keiko, Kudo, Yoshinao, Iwase, Toshio, Sugishita, Mariko, Jodoi, Takako, Ikeda, Masaaki, Ozeki, Yuji, Watanabe, Tsuyoshi, Sekimoto, Masanori, Katoh, Masaaki, Yamada, Naoto, Toyoshima, Ryoichi, Okawa, Masako, Takahashi, Kiyohisa, Yamauchi, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Substitution Biological and medical sciences Circadian Rhythm Female Fundamental and applied biological sciences. Psychology Gene Gene Frequency Genetic Carrier Screening Hormones and neuropeptides. Regulation Human Humans Hypothalamus. Hypophysis. Epiphysis. Urophysis Male melatonin 1B receptors Melatonin receptor Mutagenesis, Site-Directed Mutation, Missense Polymerase Chain Reaction Polymorphism Polymorphism, Genetic Polymorphism, Single-Stranded Conformational Receptors, Cell Surface - genetics Receptors, Cytoplasmic and Nuclear - genetics Receptors, Melatonin Reference Values Single strand conformational polymorphism analysis Sleep - physiology Sleep disorders Sleep Wake Disorders - genetics Sleep Wake Disorders - physiopathology Vertebrates: endocrinology Wakefulness - physiology
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