Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced Arthritis

ABSTRACT CIZ/NMP4 (Cas interacting zinc finger protein, Nmp4, Zfp384) is a transcription factor that is known to regulate matrix related‐proteins. To explore the possible pathophysiological role of CIZ/NMP4 in arthritis, we examined CIZ/NMP4 expression in articular cartilage in arthritis model. CIZ/...

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Veröffentlicht in:	Journal of cellular biochemistry 2016-04, Vol.117 (4), p.970-977
Hauptverfasser:	Nakamoto, Tetsuya, Izu, Yayoi, Kawasaki, Makiri, Notomi, Takuya, Hayata, Tadayoshi, Noda, Masaki, Ezura, Yoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARTHRITIS Arthritis, Experimental - chemically induced Arthritis, Experimental - genetics Arthritis, Experimental - immunology Arthritis, Experimental - pathology Autoantibodies - biosynthesis Biomedical materials Bone matrix Bone Resorption Cartilage Cartilage (articular) Cartilage, Articular - immunology Cartilage, Articular - pathology Chondrocytes Chondrocytes - immunology Chondrocytes - pathology Female Gene expression Gene Expression Regulation Glucose-6-Phosphate Isomerase - antagonists & inhibitors Glucose-6-Phosphate Isomerase - genetics Glucose-6-Phosphate Isomerase - immunology Immune Sera - administration & dosage Inflammation Interleukin-1beta - genetics Interleukin-1beta - immunology Joint diseases Joints (anatomy) Joints - immunology Joints - pathology Male Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinase 3 - immunology Mice Mice, Knockout Nuclear Matrix-Associated Proteins - deficiency Nuclear Matrix-Associated Proteins - genetics Nuclear Matrix-Associated Proteins - immunology OSTEOCALST Osteoclastogenesis Promoter Regions, Genetic Proteins RANK Ligand - genetics RANK Ligand - immunology Severity of Illness Index Signal Transduction Soft tissues TRANCE protein TRANSCRIPTION Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - immunology Transcription, Genetic Zinc finger proteins
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