Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations

Meropenem is frequently prescribed in critically ill children receiving continuous renal replacement therapy (CRRT). We previously used clinical trial simulations to evaluate dosing regimens of meropenem in this population and reported that a dose of 20 mg/kg every 12 hours optimizes target attainme...

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Veröffentlicht in:	Journal of clinical pharmacology 2016-03, Vol.56 (3), p.291-297
Hauptverfasser:	Nehus, Edward J., Mizuno, Tomoyuki, Cox, Shareen, Goldstein, Stuart L., Vinks, Alexander A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adolescent Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Antibiotics Child Child, Preschool Clinical trials Computer Simulation - standards continuous renal replacement therapy Critical Illness Female Hemodiafiltration Humans Male meropenem Microbial Sensitivity Tests pediatrics Pharmacokinetics Prospective Studies Renal replacement therapy Renal Replacement Therapy - methods Simulation Thienamycins - administration & dosage Thienamycins - blood Thienamycins - pharmacokinetics Young Adult
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