High-glucose environment increased thrombospondin-1 expression in keratinocytes via DNA hypomethylation

Diabetes is an important health issue because of its increasing prevalence and association with impaired wound healing. Epidermal keratinocytes with overexpressed antiangiogenic molecule thrombospondin-1 (TSP1) have been shown to impair proper wound healing. This study examined the potential involve...

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Veröffentlicht in:	Translational research : the journal of laboratory and clinical medicine 2016-03, Vol.169, p.91-101.e3
Hauptverfasser:	Lan, Cheng-Che E, Huang, Shu-Mei, Wu, Ching-Shuang, Wu, Chin-Han, Chen, Gwo-Shing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cells, Cultured Culture Media Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology DNA Methylation Glucose - metabolism Humans Internal Medicine Keratinocytes - metabolism Male Rats Rats, Wistar Thrombospondin 1 - metabolism Wound Healing
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