IL‐7 induces clathrin‐mediated endocytosis of CD127 and subsequent degradation by the proteasome in primary human CD8 T cells

Interleukin‐7 (IL‐7), a key immunoregulatory cytokine, plays an essential role in peripheral T‐cell homeostasis and function. Signaling via the IL‐7 receptor is tightly regulated and we and others have shown IL‐7 provides negative feedback on its own signaling by downregulating expression of the IL‐...

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Veröffentlicht in:	Immunology and cell biology 2016-02, Vol.94 (2), p.196-207
Hauptverfasser:	Faller, Elliott M, Ghazawi, Feras M, Cavar, Marko, MacPherson, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8-Positive T-Lymphocytes - immunology Cells, Cultured Clathrin - metabolism Clathrin-Coated Vesicles - metabolism Endocytosis Feedback, Physiological Homeostasis Humans Interleukin-7 - physiology Interleukin-7 Receptor alpha Subunit - metabolism Membrane Microdomains - metabolism Microscopy, Confocal Proteasome Endopeptidase Complex - metabolism Proteolysis Signal Transduction
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