Evaluating Biomaterial- and Microfluidic-Based 3D Tumor Models
Cancer is a major cause of morbidity and mortality worldwide, with a disease burden estimated to increase over the coming decades. Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail to address. Here, we review the current ‘st...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2015-11, Vol.33 (11), p.667-678 |
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| container_title | Trends in biotechnology (Regular ed.) |
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| creator | Carvalho, Mariana R Lima, Daniela Reis, Rui L Correlo, Vitor M Oliveira, Joaquim M |
| description | Cancer is a major cause of morbidity and mortality worldwide, with a disease burden estimated to increase over the coming decades. Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail to address. Here, we review the current ‘state-of-the-art’ in 3D tissue-engineering (TE) models developed for, and used in, cancer research. We assess the potential for scaffold-based TE models and microfluidics to fill the gap between 2D models and clinical application. We also discuss recent advances in combining the principles of 3D TE models and microfluidics, with a special focus on biomaterials and the most promising chip-based 3D models. |
| doi_str_mv | 10.1016/j.tibtech.2015.09.009 |
| format | Article |
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Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail to address. Here, we review the current ‘state-of-the-art’ in 3D tissue-engineering (TE) models developed for, and used in, cancer research. We assess the potential for scaffold-based TE models and microfluidics to fill the gap between 2D models and clinical application. 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Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail to address. Here, we review the current ‘state-of-the-art’ in 3D tissue-engineering (TE) models developed for, and used in, cancer research. We assess the potential for scaffold-based TE models and microfluidics to fill the gap between 2D models and clinical application. 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Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail to address. Here, we review the current ‘state-of-the-art’ in 3D tissue-engineering (TE) models developed for, and used in, cancer research. We assess the potential for scaffold-based TE models and microfluidics to fill the gap between 2D models and clinical application. We also discuss recent advances in combining the principles of 3D TE models and microfluidics, with a special focus on biomaterials and the most promising chip-based 3D models.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26603572</pmid><doi>10.1016/j.tibtech.2015.09.009</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Advantages Angiogenesis Biocompatibility Biomaterials Biomedical materials Breast cancer cancer microenvironment Cell culture Collagen drug discovery Gene expression Heterogeneity Humans Hydrogels Internal Medicine Mechanical properties Medical research microfluidics Microfluidics - methods Models, Biological Neoplasms - physiopathology Ovarian cancer Physiology Polyethylene glycol Prostate cancer Studies Synthetic products Tissue Engineering - methods Tumors |
| title | Evaluating Biomaterial- and Microfluidic-Based 3D Tumor Models |
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