Inhibition of Natural Killer Cell–Mediated Cytotoxicity by Kaposi's Sarcoma–Associated Herpesvirus K5 Protein

Kaposi's sarcoma–associated herpesvirus (KSHV) K3 and K5 proteins dramatically downregulate MHC class I molecules. However, although MHC class I downregulation may protect KSHV-infected cells from cytotoxic T lymphocyte recognition, these cells become potential targets for natural killer (NK) c...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2000-09, Vol.13 (3), p.365-374
Hauptverfasser:	Ishido, Satoshi, Choi, Joong-Kook, Lee, Bok-Soo, Wang, Chunyang, DeMaria, Maryann, Johnson, R.Paul, Cohen, George B., Jung, Jae U.
Format:	Artikel
Sprache:	eng
Schlagworte:	AK5 protein Antigens, CD - biosynthesis Antigens, CD - physiology B7-2 Antigen Cell Membrane - immunology Cell Membrane - virology Cytoplasm - immunology Cytoplasm - virology Cytotoxicity, Immunologic - immunology Down-Regulation - immunology Drug Synergism Herpesvirus 8, Human - immunology Humans Immediate-Early Proteins - biosynthesis Immediate-Early Proteins - physiology Immunity, Innate Immunosuppressive Agents - pharmacology intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - physiology K5 protein Kaposi's sarcoma-associated herpesvirus Killer Cells, Natural - immunology Killer Cells, Natural - virology Lymphocyte Activation - immunology Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - physiology Tumor Cells, Cultured - immunology Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - virology
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