Paecilosetin, a new bioactive fungal metabolite from a New Zealand isolate of Paecilomyces farinosus

A new tetramic acid derivative, paecilosetin (1), along with a recently characterized N-hydroxypyridone, farinosone B (2), was isolated from the fungus Paecilomyces farinosus. Each compound showed activity against the P388 cell line with IC50 values of 3.1 and 1.1 microg/mL, respectively. Paeciloset...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-05, Vol.68 (5), p.810-811
Hauptverfasser:	Lang, G, Blunt, J.W, Cummings, N.J, Cole, A.L.J, Munro, M.H.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology antibacterial properties Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents anticarcinogenic activity Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology antifungal properties Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Applied microbiology Bacillus subtilis - drug effects Biological and medical sciences chemical structure Chemotherapic agents Cladosporium - drug effects cultured cells cytotoxicity Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Inhibitory Concentration 50 Leukemia P388 mice Microbial Sensitivity Tests Microbiology Molecular Structure New Zealand Paecilomyces - chemistry Paecilomyces farinosus paecilosetin Pyridones - chemistry Pyridones - isolation & purification Pyridones - pharmacology pyrrolidines Pyrrolidinones - chemistry Pyrrolidinones - isolation & purification Pyrrolidinones - pharmacology spectral analysis tetramic acid Trichophyton - drug effects
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Beschreibung
Zusammenfassung:	A new tetramic acid derivative, paecilosetin (1), along with a recently characterized N-hydroxypyridone, farinosone B (2), was isolated from the fungus Paecilomyces farinosus. Each compound showed activity against the P388 cell line with IC50 values of 3.1 and 1.1 microg/mL, respectively. Paecilosetin was also active against the microorganisms Bacillus subtilis, Trichophyton mentagrophytes, and Cladosporium resinae.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0500979