Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils

The signaling factors that direct the rapid shedding of L‐selectin from neutrophils upon chemoattractant stimulation are poorly understood. Protein kinase C (PKC) has been implicated, yet previous studies have relied on the use of phorbol esters and nonselective kinase inhibitors. We treated neutrop...

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Veröffentlicht in:	Journal of leukocyte biology 2000-03, Vol.67 (3), p.415-422
Hauptverfasser:	Alexander, Shelia R., Kishimoto, Takashi K., Walcheck, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - antagonists & inhibitors Acetophenones - pharmacology Antigens, CD - metabolism Benzopyrans - antagonists & inhibitors Benzopyrans - pharmacology Cells, Cultured Chemotactic Factors - pharmacology Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic GMP-Dependent Protein Kinases Dipeptides - pharmacology Down-Regulation - drug effects formyl peptide Humans Hydroxamic Acids - pharmacology L-selectin L-Selectin - chemistry L-Selectin - metabolism Mac‐1 Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - metabolism N-formyl-Met-Leu-Phe N-Formylmethionine Leucyl-Phenylalanine - antagonists & inhibitors N-Formylmethionine Leucyl-Phenylalanine - pharmacology Naphthalenes - antagonists & inhibitors Naphthalenes - pharmacology Neutrophil Activation Neutrophils - drug effects Neutrophils - enzymology Neutrophils - immunology Neutrophils - metabolism phorbol 12-myristate 13-acetate Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism protein kinase C inhibitors Protein Kinase Inhibitors Protein Kinases - metabolism Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism shedding Staurosporine - pharmacology Tetradecanoylphorbol Acetate - antagonists & inhibitors Tetradecanoylphorbol Acetate - pharmacology
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