Targeted disruption of the epidermal growth factor receptor inhibits development of papillomas and carcinomas from human papillomavirus-immortalized keratinocytes

The epidermal growth factor receptor (EGF-R) is frequently overexpressed in human papillomavirus (HPV)-associated dysplasias and carcinomas, implying that it is important for the progression of keratinocytes to malignancy. We used mice with a targeted disruption of the EGF-R gene to directly examine...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-08, Vol.60 (16), p.4397-4402
Hauptverfasser:	WOODWORTH, C. D, GAIOTTI, D, MICHAEL, E, HANSEN, L, NEES, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogens Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - prevention & control Carcinoma, Squamous Cell - virology Cell Line, Transformed Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Viral Cocarcinogenesis Disease Progression E6 gene E7 gene EGF-R gene Fundamental and applied biological sciences. Psychology Gene Expression Genes, ras - genetics Genotype human papillomavirus Humans Keratinocytes - pathology Keratinocytes - transplantation Keratinocytes - virology Mice Mice, Inbred BALB C Mice, Nude Molecular and cellular biology Mutation Oncogene Proteins, Viral - genetics Papilloma - chemically induced Papilloma - prevention & control Papilloma - virology Papillomaviridae - genetics Papillomavirus E7 Proteins Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - physiology Repressor Proteins Skin Neoplasms - prevention & control Skin Neoplasms - virology Tetradecanoylphorbol Acetate
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