Structure and Mechanism of the Alkyl Hydroperoxidase AhpC, a Key Element of the Mycobacterium tuberculosis Defense System against Oxidative Stress

The peroxiredoxin AhpC from Mycobacterium tuberculosis (MtAhpC) is the foremost element of a NADH-dependent peroxidase and peroxynitrite reductase system, where it directly reduces peroxides and peroxynitrite and is in turn reduced by AhpD and other proteins. Overexpression of MtAhpC in isoniazid-re...

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Veröffentlicht in:	The Journal of biological chemistry 2005-07, Vol.280 (27), p.25735-25742
Hauptverfasser:	Guimarães, Beatriz G, Souchon, Hélène, Honoré, Nadine, Saint-Joanis, Brigitte, Brosch, Roland, Shepard, William, Cole, Stewart T, Alzari, Pedro M
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography Drug Design Mutagenesis, Site-Directed Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Oxidative Stress - physiology Peroxidases - chemistry Peroxidases - genetics Peroxidases - metabolism Peroxiredoxins Protein Structure, Quaternary Protein Structure, Secondary Protein Structure, Tertiary
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