ETHYL GLUCURONIDE IN HUMAN HAIR
Ethyl glucuronide (EtG) is considered to be a promising candidate marker of alcohol consumption, but exhibits a short window of detection in blood or urine. Keratinized tissues are known to retain foreign substances and to provide a greater retrospective window of detection than body fluids. Therefo...
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| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 2000-05, Vol.35 (3), p.283-285 |
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| container_title | Alcohol and alcoholism (Oxford) |
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| creator | SKOPP, GISELA SCHMITT, GEORG PÖTSCH, LUCIA DRÖNNER, PETER ADERJAN, ROLF MATTERN, RAINER |
| description | Ethyl glucuronide (EtG) is considered to be a promising candidate marker of alcohol consumption, but exhibits a short window of detection in blood or urine. Keratinized tissues are known to retain foreign substances and to provide a greater retrospective window of detection than body fluids. Therefore, post-mortem hair, skin swabs, and stratum corneum samples were collected from four subjects with a reported history of alcohol misuse and from seven subjects with a report of regular, socially accepted drinking behaviour, and were investigated for EtG. Additionally, certain specimens were collected from three children, who had not yet consumed any alcoholic beverages. EtG was detectable in most of the hair and stratum corneum samples as well as in perspiration stains from alcohol-consuming subjects. The results indicated that EtG might be formed locally in very small and highly variable amounts. The most important finding was that EtG cannot be expected to be generally detectable in keratinized tissues or perspiration stains from alcohol-drinking subjects, whereas a positive result is always associated with recent alcohol consumption. |
| doi_str_mv | 10.1093/alcalc/35.3.283 |
| format | Article |
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The most important finding was that EtG cannot be expected to be generally detectable in keratinized tissues or perspiration stains from alcohol-drinking subjects, whereas a positive result is always associated with recent alcohol consumption.</description><identifier>ISSN: 0735-0414</identifier><identifier>ISSN: 1464-3502</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/35.3.283</identifier><identifier>PMID: 10869249</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Alcohol Drinking ; Alcoholism - diagnosis ; Alcoholism and acute alcohol poisoning ; Biological and medical sciences ; Biomarkers - analysis ; Case-Control Studies ; ethyl glucuronide ; Glucuronates - analysis ; Hair - chemistry ; Humans ; Medical sciences ; Skin - chemistry ; Toxicology</subject><ispartof>Alcohol and alcoholism (Oxford), 2000-05, Vol.35 (3), p.283-285</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) May 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-7a1e6b07885f4496ee66bf8e7d8d7f5c9a93217b53c2e60a9799c8ff0adb10613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1396923$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10869249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SKOPP, GISELA</creatorcontrib><creatorcontrib>SCHMITT, GEORG</creatorcontrib><creatorcontrib>PÖTSCH, LUCIA</creatorcontrib><creatorcontrib>DRÖNNER, PETER</creatorcontrib><creatorcontrib>ADERJAN, ROLF</creatorcontrib><creatorcontrib>MATTERN, RAINER</creatorcontrib><title>ETHYL GLUCURONIDE IN HUMAN HAIR</title><title>Alcohol and alcoholism (Oxford)</title><addtitle>Alcohol and Alcoholism</addtitle><description>Ethyl glucuronide (EtG) is considered to be a promising candidate marker of alcohol consumption, but exhibits a short window of detection in blood or urine. 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The most important finding was that EtG cannot be expected to be generally detectable in keratinized tissues or perspiration stains from alcohol-drinking subjects, whereas a positive result is always associated with recent alcohol consumption.</description><subject>Alcohol Drinking</subject><subject>Alcoholism - diagnosis</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Case-Control Studies</subject><subject>ethyl glucuronide</subject><subject>Glucuronates - analysis</subject><subject>Hair - chemistry</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Skin - chemistry</subject><subject>Toxicology</subject><issn>0735-0414</issn><issn>1464-3502</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0M1PwjAYBvDGaATRszclxngbtHv7sR4JIsNMSJAhemm60SXg-HBlif73loyoMWnaQ3_v0-ZB6JLgFsES2jpP3WoDa0HLD-AI1Qnl1AOG_WNUxwKYhymhNXRm7RJjQsEnp6hGcMClT2UdXfcm4WvU7EdxNx6PhoP7XnMwbIbxU8ftncH4HJ1kOrfm4nA2UPzQm3RDLxr1B91O5KWUyZ0nNDE8wSIIWEap5MZwnmSBEfNgLjKWSi3dyyJhkPqGYy2FlGmQZVjPE4I5gQa6q3K3xeajNHanVgubmjzXa7MprSKCA-E-OHjzDy43ZbF2f1NEBoCllL5D7QqlxcbawmRqWyxWuvhSBKt9caoqTgFToFxxbuLqEFsmKzP_46umHLg9AG3daFbodbqwvw6kc_scr2ILuzOfP9e6eFdcgGAqnL0pwp6n08eXRzWDbxougLQ</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>SKOPP, GISELA</creator><creator>SCHMITT, GEORG</creator><creator>PÖTSCH, LUCIA</creator><creator>DRÖNNER, PETER</creator><creator>ADERJAN, ROLF</creator><creator>MATTERN, RAINER</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope></search><sort><creationdate>20000501</creationdate><title>ETHYL GLUCURONIDE IN HUMAN HAIR</title><author>SKOPP, GISELA ; SCHMITT, GEORG ; PÖTSCH, LUCIA ; DRÖNNER, PETER ; ADERJAN, ROLF ; MATTERN, RAINER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-7a1e6b07885f4496ee66bf8e7d8d7f5c9a93217b53c2e60a9799c8ff0adb10613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Alcohol Drinking</topic><topic>Alcoholism - diagnosis</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Case-Control Studies</topic><topic>ethyl glucuronide</topic><topic>Glucuronates - analysis</topic><topic>Hair - chemistry</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Skin - chemistry</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SKOPP, GISELA</creatorcontrib><creatorcontrib>SCHMITT, GEORG</creatorcontrib><creatorcontrib>PÖTSCH, LUCIA</creatorcontrib><creatorcontrib>DRÖNNER, PETER</creatorcontrib><creatorcontrib>ADERJAN, ROLF</creatorcontrib><creatorcontrib>MATTERN, RAINER</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SKOPP, GISELA</au><au>SCHMITT, GEORG</au><au>PÖTSCH, LUCIA</au><au>DRÖNNER, PETER</au><au>ADERJAN, ROLF</au><au>MATTERN, RAINER</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ETHYL GLUCURONIDE IN HUMAN HAIR</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol and Alcoholism</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>35</volume><issue>3</issue><spage>283</spage><epage>285</epage><pages>283-285</pages><issn>0735-0414</issn><issn>1464-3502</issn><eissn>1464-3502</eissn><abstract>Ethyl glucuronide (EtG) is considered to be a promising candidate marker of alcohol consumption, but exhibits a short window of detection in blood or urine. Keratinized tissues are known to retain foreign substances and to provide a greater retrospective window of detection than body fluids. Therefore, post-mortem hair, skin swabs, and stratum corneum samples were collected from four subjects with a reported history of alcohol misuse and from seven subjects with a report of regular, socially accepted drinking behaviour, and were investigated for EtG. Additionally, certain specimens were collected from three children, who had not yet consumed any alcoholic beverages. EtG was detectable in most of the hair and stratum corneum samples as well as in perspiration stains from alcohol-consuming subjects. The results indicated that EtG might be formed locally in very small and highly variable amounts. The most important finding was that EtG cannot be expected to be generally detectable in keratinized tissues or perspiration stains from alcohol-drinking subjects, whereas a positive result is always associated with recent alcohol consumption.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10869249</pmid><doi>10.1093/alcalc/35.3.283</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alcohol Drinking Alcoholism - diagnosis Alcoholism and acute alcohol poisoning Biological and medical sciences Biomarkers - analysis Case-Control Studies ethyl glucuronide Glucuronates - analysis Hair - chemistry Humans Medical sciences Skin - chemistry Toxicology |
| title | ETHYL GLUCURONIDE IN HUMAN HAIR |
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