Nitric Oxide Inhibits the Tumor Necrosis Factor α-regulated Endocytosis of Human Dendritic Cells in a Cyclic GMP-dependent Way

Tumor necrosis factor-α (TNFα)-induced maturation of dendritic cells (DC), with down-regulation of their endocytic ability, has been reported to be mediated by the accumulation of the lipid messenger ceramide. We have now studied the effects and mechanisms of action of NO on endocytosis, investigate...

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Veröffentlicht in:	The Journal of biological chemistry 2000-06, Vol.275 (26), p.19638-19644
Hauptverfasser:	Paolucci, Clara, Rovere, Patrizia, De Nadai, Céline, Manfredi, Angelo A., Clementi, Emilio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Brain - metabolism Cells, Cultured Ceramides - pharmacokinetics Coculture Techniques cyclic GMP Cyclic GMP - metabolism Dendritic Cells - metabolism Down-Regulation Endocytosis - physiology Enzyme Inhibitors - pharmacokinetics Flow Cytometry fluorescein isothiocyanate Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans Interleukin-4 - pharmacology Leukocytes, Mononuclear - metabolism Lipopolysaccharides - metabolism Mice nitric oxide Nitric Oxide - pharmacology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Sphingosine - analogs & derivatives Sphingosine - pharmacokinetics Time Factors Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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