Osteonecrosis of the hip, lipodystrophy and antiretroviral treatment
Fat distribution abnormalities and metabolic disturbances in HIV-infected patients receiving antiretroviral therapy have been extensively described during the past 3 years. The so-called `lipodystrophic syndromes' associate, to varying degrees, features of face and limb lipoatrophy, truncal obe...
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| Veröffentlicht in: | AIDS (London) 2000-09, Vol.14 (13), p.2056-2056 |
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| container_title | AIDS (London) |
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| creator | ROUDIERE, Laurent VIARD, Jean-Paul |
| description | Fat distribution abnormalities and metabolic disturbances in HIV-infected patients receiving antiretroviral therapy have been extensively described during the past 3 years. The so-called `lipodystrophic syndromes' associate, to varying degrees, features of face and limb lipoatrophy, truncal obesity, visceral fat accumulation, hypercholesterolaemia and hypertriglyceridaemia, as well as insulin resistance, leading in some cases to overt diabetes. No consensus has been reached to date for a case definition of this syndrome, and its pathogeny remains obscure although antiretroviral drugs are most probably involved. We report on six patients (out of a cohort of 508 HIV-infected patients, including 280 on triple antiretroviral treatment) who were diagnosed with bilateral avascular necrosis of the femoral head, all between 1998 and January 2000. |
| doi_str_mv | 10.1097/00002030-200009080-00026 |
| format | Article |
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The so-called `lipodystrophic syndromes' associate, to varying degrees, features of face and limb lipoatrophy, truncal obesity, visceral fat accumulation, hypercholesterolaemia and hypertriglyceridaemia, as well as insulin resistance, leading in some cases to overt diabetes. No consensus has been reached to date for a case definition of this syndrome, and its pathogeny remains obscure although antiretroviral drugs are most probably involved. 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We report on six patients (out of a cohort of 508 HIV-infected patients, including 280 on triple antiretroviral treatment) who were diagnosed with bilateral avascular necrosis of the femoral head, all between 1998 and January 2000.</description><subject>Adult</subject><subject>Anti-HIV Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Femur Head</subject><subject>HIV Infections - drug therapy</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Lipodystrophy - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Osteonecrosis - complications</subject><subject>Pharmacology. 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Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROUDIERE, Laurent</creatorcontrib><creatorcontrib>VIARD, Jean-Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROUDIERE, Laurent</au><au>VIARD, Jean-Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteonecrosis of the hip, lipodystrophy and antiretroviral treatment</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2000-09-08</date><risdate>2000</risdate><volume>14</volume><issue>13</issue><spage>2056</spage><epage>2056</epage><pages>2056-2056</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>Fat distribution abnormalities and metabolic disturbances in HIV-infected patients receiving antiretroviral therapy have been extensively described during the past 3 years. The so-called `lipodystrophic syndromes' associate, to varying degrees, features of face and limb lipoatrophy, truncal obesity, visceral fat accumulation, hypercholesterolaemia and hypertriglyceridaemia, as well as insulin resistance, leading in some cases to overt diabetes. No consensus has been reached to date for a case definition of this syndrome, and its pathogeny remains obscure although antiretroviral drugs are most probably involved. We report on six patients (out of a cohort of 508 HIV-infected patients, including 280 on triple antiretroviral treatment) who were diagnosed with bilateral avascular necrosis of the femoral head, all between 1998 and January 2000.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10997415</pmid><doi>10.1097/00002030-200009080-00026</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | AIDS (London), 2000-09, Vol.14 (13), p.2056-2056 |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Anti-HIV Agents - adverse effects Biological and medical sciences Drug toxicity and drugs side effects treatment Femur Head HIV Infections - drug therapy Human immunodeficiency virus Humans Lipodystrophy - complications Male Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Osteonecrosis - complications Pharmacology. Drug treatments |
| title | Osteonecrosis of the hip, lipodystrophy and antiretroviral treatment |
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