Chemopreventive agents targeting tumor microenvironment

Recent studies have shown that tumor development and progression depend not only on the perturbed genes that govern cell proliferation, but is also highly determined by the non-tumor cells of the stromal compartment surrounding the tumor called tumor microenvironment (TME). These findings highlight...

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Veröffentlicht in:	Life sciences (1973) 2016-01, Vol.145, p.74-84
Hauptverfasser:	Sharma, Sharada H., Thulasingam, Senthilkumar, Nagarajan, Sangeetha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer agents Anticarcinogenic Agents - pharmacology Chemoprevention Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - pathology Fibroblasts - drug effects Fibroblasts - immunology Fibroblasts - pathology Humans Immune cells Immunity, Cellular - drug effects Lymphocytes - drug effects Lymphocytes - immunology Lymphocytes - pathology Macrophages - immunology Macrophages - pathology Mast cells Mast Cells - drug effects Mast Cells - immunology Mast Cells - pathology Neoplasms - immunology Neoplasms - pathology Neoplasms - prevention & control Pericytes - drug effects Pericytes - immunology Pericytes - pathology Tumor endothelial cells Tumor microenvironment Tumor Microenvironment - drug effects
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