The enzyme l-isoaspartyl (d-aspartyl) methyltransferase is required for VEGF-dependent endothelial cell migration and tubulogenesis

The protein l -isoaspartyl ( d -aspartyl) methyltransferase (PIMT) methylates proteins carrying altered aspartyl residues in their structure. PIMT is postulated to limit the accumulation of these damaged proteins with abnormal aspartyl residues. However, little is known about the role of PIMT in tum...

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Veröffentlicht in:	Molecular and cellular biochemistry 2016-02, Vol.413 (1-2), p.37-46
Hauptverfasser:	Ouanouki, Amira, Desrosiers, Richard R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Biochemistry Biomedical and Life Sciences Cardiology Cell adhesion & migration Cell Movement - drug effects Down-Regulation Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelium Enzymes Human Umbilical Vein Endothelial Cells Humans Life Sciences Medical Biochemistry Neovascularization, Physiologic Oncology Protein D-Aspartate-L-Isoaspartate Methyltransferase - genetics Protein D-Aspartate-L-Isoaspartate Methyltransferase - metabolism Proteins Transferases Vascular endothelial growth factor Vascular Endothelial Growth Factor A - pharmacology
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