Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole genome amplification

Objective To develop a novel and robust protocol for multifactorial preimplantation genetic testing of trophectoderm biopsies using quantitative polymerase chain reaction (qPCR). Design Prospective and blinded. Setting Not applicable. Patient(s) Couples indicated for preimplantation genetic diagnosi...

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Veröffentlicht in:	Fertility and sterility 2016-02, Vol.105 (2), p.286-294
Hauptverfasser:	Zimmerman, Rebekah S., Ph.D., F.A.C.M.G, Jalas, Chaim, Tao, Xin, M.S, Fedick, Anastasia M., Ph.D, Kim, Julia G., M.D, Pepe, Russell J., B.S, Northrop, Lesley E., Ph.D, Scott, Richard T., M.D., H.C.L.D, Treff, Nathan R., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Biopsy Chromosome Aberrations Embryo Transfer Female Fertility Fertilization in Vitro Genetic Diseases, Inborn - diagnosis Genetic Diseases, Inborn - genetics Genetic Testing - methods Humans Infertility - diagnosis Infertility - physiopathology Infertility - therapy Internal Medicine Male monogenic disorder Obstetrics and Gynecology Polymerase Chain Reaction Predictive Value of Tests Pregnancy Pregnancy Rate Preimplantation Diagnosis - methods preimplantation genetic diagnosis Prospective Studies Reproducibility of Results Single gene disorder Treatment Outcome trophectoderm
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