Non-alkaloid constituents of Vinca major
The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination...
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| Veröffentlicht in: | Chinese journal of natural medicines 2016, Vol.14 (1), p.56-60 |
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| container_title | Chinese journal of natural medicines |
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| creator | CHENG, Gui-Guang ZHAO, Hai-Yun LIU, Lu ZHAO, Yun-Li SONG, Chang-Wei GU, Ji SUN, Wei-Bang LIU, Ya-Ping LUO, Xiao-Dong |
| description | The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl （DPPH）-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside （compound 1）, together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2μmaol·L 1, respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity. |
| doi_str_mv | 10.3724/SP.J.1009.2016.00056 |
| format | Article |
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The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl （DPPH）-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside （compound 1）, together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2μmaol·L 1, respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.</description><identifier>ISSN: 2095-6975</identifier><identifier>ISSN: 1875-5364</identifier><identifier>EISSN: 1875-5364</identifier><identifier>DOI: 10.3724/SP.J.1009.2016.00056</identifier><identifier>PMID: 26850347</identifier><language>eng</language><publisher>China: Elsevier B.V</publisher><subject>Antioxidant ; Antioxidants - pharmacology ; Iridoid glycoside ; Iridoid Glycosides - chemistry ; Iridoid Glycosides - isolation & purification ; Iridoid Glycosides - pharmacology ; Plant Leaves - chemistry ; Plant Stems - chemistry ; Vinca - chemistry ; Vinca major ; Vinmaside A ; 成分 ; 技术分离 ; 抗氧化活性 ; 清除DPPH活性 ; 环烯醚萜苷 ; 生物碱类化合物 ; 长春花 ; 非生物碱</subject><ispartof>Chinese journal of natural medicines, 2016, Vol.14 (1), p.56-60</ispartof><rights>2016 China Pharmaceutical University</rights><rights>Copyright © 2016 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86968X/86968X.jpg</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3724/SP.J.1009.2016.00056$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26850347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHENG, Gui-Guang</creatorcontrib><creatorcontrib>ZHAO, Hai-Yun</creatorcontrib><creatorcontrib>LIU, Lu</creatorcontrib><creatorcontrib>ZHAO, Yun-Li</creatorcontrib><creatorcontrib>SONG, Chang-Wei</creatorcontrib><creatorcontrib>GU, Ji</creatorcontrib><creatorcontrib>SUN, Wei-Bang</creatorcontrib><creatorcontrib>LIU, Ya-Ping</creatorcontrib><creatorcontrib>LUO, Xiao-Dong</creatorcontrib><title>Non-alkaloid constituents of Vinca major</title><title>Chinese journal of natural medicines</title><addtitle>Chinese JOurnal of Natural Medicines</addtitle><description>The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl （DPPH）-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside （compound 1）, together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2μmaol·L 1, respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.</description><subject>Antioxidant</subject><subject>Antioxidants - pharmacology</subject><subject>Iridoid glycoside</subject><subject>Iridoid Glycosides - chemistry</subject><subject>Iridoid Glycosides - isolation & purification</subject><subject>Iridoid Glycosides - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Plant Stems - chemistry</subject><subject>Vinca - chemistry</subject><subject>Vinca major</subject><subject>Vinmaside A</subject><subject>成分</subject><subject>技术分离</subject><subject>抗氧化活性</subject><subject>清除DPPH活性</subject><subject>环烯醚萜苷</subject><subject>生物碱类化合物</subject><subject>长春花</subject><subject>非生物碱</subject><issn>2095-6975</issn><issn>1875-5364</issn><issn>1875-5364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAURC0EolXpHyAUseomwY_YTjZIqOJVVVCpwNbyK8WQ2m2cIPH3pLRwN7MZzcw9AJwjmBGO86vlIptlCMIywxCxDEJI2REYooLTlBKWH4MhhiVNWcnpAIxjdApi0h_n6BQMMCsoJDkfgslT8KmsP2UdnEl08LF1bWd9G5NQJW_Oa5ms5UdozsBJJetoxwcdgde725fpQzp_vn-c3sxTjUvSphUuGa4KKSnph1U5rhSl2kqkoTIVMkQZq5UxvFBGMUMZl1YWeam5pSXNCRmByT5304RtZ2Mr1i5qW9fS29BFgTjrK3LYt43AxcHaqbU1YtO4tWy-xd93veF6b7D94C9nGxG1s15b4xqrW2GCEwiKHVGxXIiZ2BEVO6Lil2gfcLkP0O_Br7bOr_5LGOOcIIog-QHfIXIt</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>CHENG, Gui-Guang</creator><creator>ZHAO, Hai-Yun</creator><creator>LIU, Lu</creator><creator>ZHAO, Yun-Li</creator><creator>SONG, Chang-Wei</creator><creator>GU, Ji</creator><creator>SUN, Wei-Bang</creator><creator>LIU, Ya-Ping</creator><creator>LUO, Xiao-Dong</creator><general>Elsevier B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Non-alkaloid constituents of Vinca major</title><author>CHENG, Gui-Guang ; ZHAO, Hai-Yun ; LIU, Lu ; ZHAO, Yun-Li ; SONG, Chang-Wei ; GU, Ji ; SUN, Wei-Bang ; LIU, Ya-Ping ; LUO, Xiao-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-f2962f8aa53016f42fb55cea1c0bdf1d3bdecbdd78bdb6d567aea849c7e595433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antioxidant</topic><topic>Antioxidants - pharmacology</topic><topic>Iridoid glycoside</topic><topic>Iridoid Glycosides - chemistry</topic><topic>Iridoid Glycosides - isolation & purification</topic><topic>Iridoid Glycosides - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Plant Stems - chemistry</topic><topic>Vinca - chemistry</topic><topic>Vinca major</topic><topic>Vinmaside A</topic><topic>成分</topic><topic>技术分离</topic><topic>抗氧化活性</topic><topic>清除DPPH活性</topic><topic>环烯醚萜苷</topic><topic>生物碱类化合物</topic><topic>长春花</topic><topic>非生物碱</topic><toplevel>online_resources</toplevel><creatorcontrib>CHENG, Gui-Guang</creatorcontrib><creatorcontrib>ZHAO, Hai-Yun</creatorcontrib><creatorcontrib>LIU, Lu</creatorcontrib><creatorcontrib>ZHAO, Yun-Li</creatorcontrib><creatorcontrib>SONG, Chang-Wei</creatorcontrib><creatorcontrib>GU, Ji</creatorcontrib><creatorcontrib>SUN, Wei-Bang</creatorcontrib><creatorcontrib>LIU, Ya-Ping</creatorcontrib><creatorcontrib>LUO, Xiao-Dong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chinese journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHENG, Gui-Guang</au><au>ZHAO, Hai-Yun</au><au>LIU, Lu</au><au>ZHAO, Yun-Li</au><au>SONG, Chang-Wei</au><au>GU, Ji</au><au>SUN, Wei-Bang</au><au>LIU, Ya-Ping</au><au>LUO, Xiao-Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-alkaloid constituents of Vinca major</atitle><jtitle>Chinese journal of natural medicines</jtitle><addtitle>Chinese JOurnal of Natural Medicines</addtitle><date>2016</date><risdate>2016</risdate><volume>14</volume><issue>1</issue><spage>56</spage><epage>60</epage><pages>56-60</pages><issn>2095-6975</issn><issn>1875-5364</issn><eissn>1875-5364</eissn><abstract>The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl （DPPH）-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside （compound 1）, together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2μmaol·L 1, respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.</abstract><cop>China</cop><pub>Elsevier B.V</pub><pmid>26850347</pmid><doi>10.3724/SP.J.1009.2016.00056</doi><tpages>5</tpages></addata></record> |
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| subjects | Antioxidant Antioxidants - pharmacology Iridoid glycoside Iridoid Glycosides - chemistry Iridoid Glycosides - isolation & purification Iridoid Glycosides - pharmacology Plant Leaves - chemistry Plant Stems - chemistry Vinca - chemistry Vinca major Vinmaside A 成分 技术分离 抗氧化活性 清除DPPH活性 环烯醚萜苷 生物碱类化合物 长春花 非生物碱 |
| title | Non-alkaloid constituents of Vinca major |
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