Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Hypothyroidism in Canadian Women
Context: Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a wide range of products, resulting in widespread human exposure. Epidemiological studies in some populations reported exposure to PBDEs and thyroid hormone levels but little epidemiological data are available among wome...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2016-02, Vol.101 (2), p.590-598 |
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| creator | Oulhote, Youssef Chevrier, Jonathan Bouchard, Maryse F |
| description | Context:
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a wide range of products, resulting in widespread human exposure. Epidemiological studies in some populations reported exposure to PBDEs and thyroid hormone levels but little epidemiological data are available among women from the general population.
Objective:
The objective of the study was to examine the association of PBDEs with hypothyroidism.
Design and Setting:
This was a cross-sectional analysis of the 2007–2009 Canadian Health Measures Survey.
Participants:
A total of 745 women representative of Canadian women aged 30–79 years participated in the study.
Main Outcome and Methods:
We estimated the prevalence ratios (PRs) for hypothyroidism in relation to plasma concentrations of BDE-47, -99, -100, and -153 and their sum (ΣPBDEs). Women were identified as cases if they reported a doctor-diagnosed thyroid condition and underwent thyroid hormone replacement therapy (n = 90).
Results:
Higher plasma levels of brominated diphenyl ether (BDE)-47 and -100 and ΣPBDEs were associated with an increased prevalence of hypothyroidism. The PR for a 10-fold increase in ΣPBDEs was 1.7 (95% confidence interval [CI] 1.0, 3.0). Associations were consistently higher among women aged 30–50 years than among those 51–79 years for ΣPBDEs and the other PBDE congeners, although the interaction was significant only for BDE-100. For instance, in the younger age group, women with detectable levels of BDE-100 had a PR of 3.8 (95% CI 1.2, 12.3) compared with women with undetectable levels; the corresponding PR in the older age group was 1.2 (95% CI 0.6, 2.3). No association was observed for BDE-99 and -153.
Conclusion:
Plasma PBDE levels were associated with an increased prevalence of hypothyroidism in Canadian women aged 30–50 years. Although the cross-sectional design of the study limits inferences of causality, these findings have important implications, given the key role of thyroid hormones in several biological mechanisms during reproductive age. |
| doi_str_mv | 10.1210/jc.2015-2659 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1762961527</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1762961527</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4188-b8ee4d904f293ba039c7c2c8104a4c8dd744bfd4606c7010c46b3f3265f88de73</originalsourceid><addsrcrecordid>eNptkEFr3DAQRkVpaDZpbz0XHVOIE0mWJfvYbrZNIJAcWtKbkKUx1taWXMkm9b-vlk17qmAQA28-Zh5C7ym5ooyS6725YoRWBRNV8wptaMOrQtJGvkYbQhgtGsl-nKKzlPaEUM6r8g06ZUIQIWSzQU-731NISwQ8B_wYhrWNYXRez2DxjZt68OuAd3MPMeGLx883u_QRa2_x7TqFuV9jcNalETuPt9pr67THT2EE_xaddHpI8O7lP0ffv-y-bW-L-4evd9tP94XhtK6LtgbgtiG8Y03ZalI2Rhpmakq45qa2VnLedpbndY0klBgu2rIr861dXVuQ5Tm6OOZOMfxaIM1qdMnAMGgPYUmKSsEaQSt2QC-PqIkhpQidmqIbdVwVJeqgUu2NOqhUB5UZ__CSvLQj2H_wX3cZ4EfgOQxz9vNzWJ4hqh70MPeK5MeFrIucKAjLXZGL1XmsPI6Bt8FE52GKkJLahyX6rOr_2_wBxcuO6A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1762961527</pqid></control><display><type>article</type><title>Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Hypothyroidism in Canadian Women</title><source>Journals@Ovid Ovid Autoload</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Oulhote, Youssef ; Chevrier, Jonathan ; Bouchard, Maryse F</creator><creatorcontrib>Oulhote, Youssef ; Chevrier, Jonathan ; Bouchard, Maryse F</creatorcontrib><description>Context:
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a wide range of products, resulting in widespread human exposure. Epidemiological studies in some populations reported exposure to PBDEs and thyroid hormone levels but little epidemiological data are available among women from the general population.
Objective:
The objective of the study was to examine the association of PBDEs with hypothyroidism.
Design and Setting:
This was a cross-sectional analysis of the 2007–2009 Canadian Health Measures Survey.
Participants:
A total of 745 women representative of Canadian women aged 30–79 years participated in the study.
Main Outcome and Methods:
We estimated the prevalence ratios (PRs) for hypothyroidism in relation to plasma concentrations of BDE-47, -99, -100, and -153 and their sum (ΣPBDEs). Women were identified as cases if they reported a doctor-diagnosed thyroid condition and underwent thyroid hormone replacement therapy (n = 90).
Results:
Higher plasma levels of brominated diphenyl ether (BDE)-47 and -100 and ΣPBDEs were associated with an increased prevalence of hypothyroidism. The PR for a 10-fold increase in ΣPBDEs was 1.7 (95% confidence interval [CI] 1.0, 3.0). Associations were consistently higher among women aged 30–50 years than among those 51–79 years for ΣPBDEs and the other PBDE congeners, although the interaction was significant only for BDE-100. For instance, in the younger age group, women with detectable levels of BDE-100 had a PR of 3.8 (95% CI 1.2, 12.3) compared with women with undetectable levels; the corresponding PR in the older age group was 1.2 (95% CI 0.6, 2.3). No association was observed for BDE-99 and -153.
Conclusion:
Plasma PBDE levels were associated with an increased prevalence of hypothyroidism in Canadian women aged 30–50 years. Although the cross-sectional design of the study limits inferences of causality, these findings have important implications, given the key role of thyroid hormones in several biological mechanisms during reproductive age.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2015-2659</identifier><identifier>PMID: 26606679</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Adolescent ; Adult ; Aged ; Canada - epidemiology ; Child ; Cross-Sectional Studies ; Environmental Exposure - adverse effects ; Environmental Pollutants - toxicity ; Female ; Halogenated Diphenyl Ethers - blood ; Halogenated Diphenyl Ethers - toxicity ; Health Surveys ; Humans ; Hypothyroidism - chemically induced ; Hypothyroidism - epidemiology ; Middle Aged ; Prevalence ; Socioeconomic Factors ; Young Adult</subject><ispartof>The journal of clinical endocrinology and metabolism, 2016-02, Vol.101 (2), p.590-598</ispartof><rights>Copyright © 2016 by the Endocrine Society</rights><rights>Copyright © 2016 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4188-b8ee4d904f293ba039c7c2c8104a4c8dd744bfd4606c7010c46b3f3265f88de73</citedby><cites>FETCH-LOGICAL-c4188-b8ee4d904f293ba039c7c2c8104a4c8dd744bfd4606c7010c46b3f3265f88de73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26606679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oulhote, Youssef</creatorcontrib><creatorcontrib>Chevrier, Jonathan</creatorcontrib><creatorcontrib>Bouchard, Maryse F</creatorcontrib><title>Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Hypothyroidism in Canadian Women</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a wide range of products, resulting in widespread human exposure. Epidemiological studies in some populations reported exposure to PBDEs and thyroid hormone levels but little epidemiological data are available among women from the general population.
Objective:
The objective of the study was to examine the association of PBDEs with hypothyroidism.
Design and Setting:
This was a cross-sectional analysis of the 2007–2009 Canadian Health Measures Survey.
Participants:
A total of 745 women representative of Canadian women aged 30–79 years participated in the study.
Main Outcome and Methods:
We estimated the prevalence ratios (PRs) for hypothyroidism in relation to plasma concentrations of BDE-47, -99, -100, and -153 and their sum (ΣPBDEs). Women were identified as cases if they reported a doctor-diagnosed thyroid condition and underwent thyroid hormone replacement therapy (n = 90).
Results:
Higher plasma levels of brominated diphenyl ether (BDE)-47 and -100 and ΣPBDEs were associated with an increased prevalence of hypothyroidism. The PR for a 10-fold increase in ΣPBDEs was 1.7 (95% confidence interval [CI] 1.0, 3.0). Associations were consistently higher among women aged 30–50 years than among those 51–79 years for ΣPBDEs and the other PBDE congeners, although the interaction was significant only for BDE-100. For instance, in the younger age group, women with detectable levels of BDE-100 had a PR of 3.8 (95% CI 1.2, 12.3) compared with women with undetectable levels; the corresponding PR in the older age group was 1.2 (95% CI 0.6, 2.3). No association was observed for BDE-99 and -153.
Conclusion:
Plasma PBDE levels were associated with an increased prevalence of hypothyroidism in Canadian women aged 30–50 years. Although the cross-sectional design of the study limits inferences of causality, these findings have important implications, given the key role of thyroid hormones in several biological mechanisms during reproductive age.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Canada - epidemiology</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Pollutants - toxicity</subject><subject>Female</subject><subject>Halogenated Diphenyl Ethers - blood</subject><subject>Halogenated Diphenyl Ethers - toxicity</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Hypothyroidism - chemically induced</subject><subject>Hypothyroidism - epidemiology</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Socioeconomic Factors</subject><subject>Young Adult</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFr3DAQRkVpaDZpbz0XHVOIE0mWJfvYbrZNIJAcWtKbkKUx1taWXMkm9b-vlk17qmAQA28-Zh5C7ym5ooyS6725YoRWBRNV8wptaMOrQtJGvkYbQhgtGsl-nKKzlPaEUM6r8g06ZUIQIWSzQU-731NISwQ8B_wYhrWNYXRez2DxjZt68OuAd3MPMeGLx883u_QRa2_x7TqFuV9jcNalETuPt9pr67THT2EE_xaddHpI8O7lP0ffv-y-bW-L-4evd9tP94XhtK6LtgbgtiG8Y03ZalI2Rhpmakq45qa2VnLedpbndY0klBgu2rIr861dXVuQ5Tm6OOZOMfxaIM1qdMnAMGgPYUmKSsEaQSt2QC-PqIkhpQidmqIbdVwVJeqgUu2NOqhUB5UZ__CSvLQj2H_wX3cZ4EfgOQxz9vNzWJ4hqh70MPeK5MeFrIucKAjLXZGL1XmsPI6Bt8FE52GKkJLahyX6rOr_2_wBxcuO6A</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Oulhote, Youssef</creator><creator>Chevrier, Jonathan</creator><creator>Bouchard, Maryse F</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201602</creationdate><title>Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Hypothyroidism in Canadian Women</title><author>Oulhote, Youssef ; Chevrier, Jonathan ; Bouchard, Maryse F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4188-b8ee4d904f293ba039c7c2c8104a4c8dd744bfd4606c7010c46b3f3265f88de73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Canada - epidemiology</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Pollutants - toxicity</topic><topic>Female</topic><topic>Halogenated Diphenyl Ethers - blood</topic><topic>Halogenated Diphenyl Ethers - toxicity</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Hypothyroidism - chemically induced</topic><topic>Hypothyroidism - epidemiology</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Socioeconomic Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oulhote, Youssef</creatorcontrib><creatorcontrib>Chevrier, Jonathan</creatorcontrib><creatorcontrib>Bouchard, Maryse F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oulhote, Youssef</au><au>Chevrier, Jonathan</au><au>Bouchard, Maryse F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Hypothyroidism in Canadian Women</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2016-02</date><risdate>2016</risdate><volume>101</volume><issue>2</issue><spage>590</spage><epage>598</epage><pages>590-598</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context:
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a wide range of products, resulting in widespread human exposure. Epidemiological studies in some populations reported exposure to PBDEs and thyroid hormone levels but little epidemiological data are available among women from the general population.
Objective:
The objective of the study was to examine the association of PBDEs with hypothyroidism.
Design and Setting:
This was a cross-sectional analysis of the 2007–2009 Canadian Health Measures Survey.
Participants:
A total of 745 women representative of Canadian women aged 30–79 years participated in the study.
Main Outcome and Methods:
We estimated the prevalence ratios (PRs) for hypothyroidism in relation to plasma concentrations of BDE-47, -99, -100, and -153 and their sum (ΣPBDEs). Women were identified as cases if they reported a doctor-diagnosed thyroid condition and underwent thyroid hormone replacement therapy (n = 90).
Results:
Higher plasma levels of brominated diphenyl ether (BDE)-47 and -100 and ΣPBDEs were associated with an increased prevalence of hypothyroidism. The PR for a 10-fold increase in ΣPBDEs was 1.7 (95% confidence interval [CI] 1.0, 3.0). Associations were consistently higher among women aged 30–50 years than among those 51–79 years for ΣPBDEs and the other PBDE congeners, although the interaction was significant only for BDE-100. For instance, in the younger age group, women with detectable levels of BDE-100 had a PR of 3.8 (95% CI 1.2, 12.3) compared with women with undetectable levels; the corresponding PR in the older age group was 1.2 (95% CI 0.6, 2.3). No association was observed for BDE-99 and -153.
Conclusion:
Plasma PBDE levels were associated with an increased prevalence of hypothyroidism in Canadian women aged 30–50 years. Although the cross-sectional design of the study limits inferences of causality, these findings have important implications, given the key role of thyroid hormones in several biological mechanisms during reproductive age.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>26606679</pmid><doi>10.1210/jc.2015-2659</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2016-02, Vol.101 (2), p.590-598 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1762961527 |
| source | Journals@Ovid Ovid Autoload; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Canada - epidemiology Child Cross-Sectional Studies Environmental Exposure - adverse effects Environmental Pollutants - toxicity Female Halogenated Diphenyl Ethers - blood Halogenated Diphenyl Ethers - toxicity Health Surveys Humans Hypothyroidism - chemically induced Hypothyroidism - epidemiology Middle Aged Prevalence Socioeconomic Factors Young Adult |
| title | Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Hypothyroidism in Canadian Women |
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