Epigenetic Mutation of the Succinate Dehydrogenase C Promoter in a Patient With Two Paragangliomas

Context: Mutational inactivation of the succinate dehydrogenase (SDH) complex is a well-described cause of tumor development in pheochromocytomas/paragangliomas (PPGLs) and gastrointestinal stromal tumors (GISTs). Epigenetic inactivation of the SDHC gene is a more recently discovered phenomenon, whi...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2016-02, Vol.101 (2), p.359-363
Hauptverfasser:	Richter, Susan, Klink, Barbara, Nacke, Brit, de Cubas, Aguirre A, Mangelis, Anastasios, Rapizzi, Elena, Meinhardt, Matthias, Skondra, Christina, Mannelli, Massimo, Robledo, Mercedes, Menschikowski, Mario, Eisenhofer, Graeme
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - genetics Adult Carney Complex - genetics DNA Methylation Epigenesis, Genetic Female Genetic Testing Humans Membrane Proteins - genetics Mutation - genetics Paraganglioma - genetics Pheochromocytoma - genetics
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