Highly Charged Proteins: The Achilles' Heel of Aging Proteomes

As cells and organisms age, their proteins sustain increasing amounts of oxidative damage. It is estimated that half of all proteins are damaged in old organisms, yet the dominant mechanisms by which damage affects proteins and cellular phenotypes are not known. Here, we show that random modificatio...

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Veröffentlicht in:	Structure (London) 2016-02, Vol.24 (2), p.329-336
Hauptverfasser:	de Graff, Adam M.R., Hazoglou, Michael J., Dill, Ken A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Humans Models, Molecular Oxidative Stress Protein Conformation Protein Folding Protein Stability Proteome - chemistry Static Electricity
Online-Zugang:	Volltext
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