Hemodialysis Access in the Elderly: Outcomes among Patients Older than Seventy

Background Arteriovenous fistulae (AVF) are the preferred access for hemodialysis, however, there continues to be limited data guiding the surgical management of primary dialysis access creation in elderly end-stage renal disease patients. Methods This is an 8-year retrospective institutional study...

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Veröffentlicht in:Annals of vascular surgery 2016-02, Vol.31, p.77-84
Hauptverfasser: Jadlowiec, Caroline C, Mannion, Elizabeth M, Lavallee, Matthew, Brown, Matthew G
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container_title Annals of vascular surgery
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creator Jadlowiec, Caroline C
Mannion, Elizabeth M
Lavallee, Matthew
Brown, Matthew G
description Background Arteriovenous fistulae (AVF) are the preferred access for hemodialysis, however, there continues to be limited data guiding the surgical management of primary dialysis access creation in elderly end-stage renal disease patients. Methods This is an 8-year retrospective institutional study evaluating the operative and clinical characteristics of patients 70 years or above who underwent primary, first-ever, AVF or arteriovenous graft (AVG) creation. Results There was no overall significant difference in AVF and AVG primary ( P  = 0.127) and secondary ( P  = 0.870) patency. AVG had higher graft loss secondary to infection ( P  = 0.0002) and thrombosis ( P  = 0.0213). Survival was less than 50% at 2 years for AVF and AVG patients. An equal number of AVF and AVG patients who died had functional access at the time of death ( P  = 1.0000) with more AVG patients using their graft (initiating dialysis) before death ( P  = 0.0118). Conclusions Elderly patient patency rates for AVF and AVG are satisfactory and support surgical access creation; however, overall 2-year survival is low. An equal number of AVF and AVG patients died with functioning surgical access, however, more AVG patients initiated dialysis and successfully used their access. Accordingly, special consideration needs to be given with regard to estimated timing until dialysis and predicted patient longevity. Delaying access creation until dialysis is needed and proceeding with AVG creation appears to be justified.
doi_str_mv 10.1016/j.avsg.2015.08.013
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Methods This is an 8-year retrospective institutional study evaluating the operative and clinical characteristics of patients 70 years or above who underwent primary, first-ever, AVF or arteriovenous graft (AVG) creation. Results There was no overall significant difference in AVF and AVG primary ( P  = 0.127) and secondary ( P  = 0.870) patency. AVG had higher graft loss secondary to infection ( P  = 0.0002) and thrombosis ( P  = 0.0213). Survival was less than 50% at 2 years for AVF and AVG patients. An equal number of AVF and AVG patients who died had functional access at the time of death ( P  = 1.0000) with more AVG patients using their graft (initiating dialysis) before death ( P  = 0.0118). Conclusions Elderly patient patency rates for AVF and AVG are satisfactory and support surgical access creation; however, overall 2-year survival is low. An equal number of AVF and AVG patients died with functioning surgical access, however, more AVG patients initiated dialysis and successfully used their access. Accordingly, special consideration needs to be given with regard to estimated timing until dialysis and predicted patient longevity. Delaying access creation until dialysis is needed and proceeding with AVG creation appears to be justified.</description><identifier>ISSN: 0890-5096</identifier><identifier>EISSN: 1615-5947</identifier><identifier>DOI: 10.1016/j.avsg.2015.08.013</identifier><identifier>PMID: 26616499</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Arteriovenous Shunt, Surgical - adverse effects ; Arteriovenous Shunt, Surgical - instrumentation ; Arteriovenous Shunt, Surgical - mortality ; Blood Vessel Prosthesis - adverse effects ; Blood Vessel Prosthesis Implantation - adverse effects ; Blood Vessel Prosthesis Implantation - instrumentation ; Blood Vessel Prosthesis Implantation - mortality ; Female ; Graft Occlusion, Vascular - etiology ; Graft Occlusion, Vascular - physiopathology ; Humans ; Kaplan-Meier Estimate ; Male ; Prosthesis-Related Infections - microbiology ; Renal Dialysis ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - mortality ; Renal Insufficiency, Chronic - therapy ; Retrospective Studies ; Risk Factors ; Stents - adverse effects ; Surgery ; Thrombosis - etiology ; Thrombosis - physiopathology ; Time Factors ; Treatment Outcome ; Vascular Patency</subject><ispartof>Annals of vascular surgery, 2016-02, Vol.31, p.77-84</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-b039b7728c871e08d9936893d70a6f1c2e96578604a011e4a7f7b96f9ce61ee93</citedby><cites>FETCH-LOGICAL-c411t-b039b7728c871e08d9936893d70a6f1c2e96578604a011e4a7f7b96f9ce61ee93</cites><orcidid>0000-0001-7860-9519</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0890509615007992$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26616499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jadlowiec, Caroline C</creatorcontrib><creatorcontrib>Mannion, Elizabeth M</creatorcontrib><creatorcontrib>Lavallee, Matthew</creatorcontrib><creatorcontrib>Brown, Matthew G</creatorcontrib><title>Hemodialysis Access in the Elderly: Outcomes among Patients Older than Seventy</title><title>Annals of vascular surgery</title><addtitle>Ann Vasc Surg</addtitle><description>Background Arteriovenous fistulae (AVF) are the preferred access for hemodialysis, however, there continues to be limited data guiding the surgical management of primary dialysis access creation in elderly end-stage renal disease patients. Methods This is an 8-year retrospective institutional study evaluating the operative and clinical characteristics of patients 70 years or above who underwent primary, first-ever, AVF or arteriovenous graft (AVG) creation. Results There was no overall significant difference in AVF and AVG primary ( P  = 0.127) and secondary ( P  = 0.870) patency. AVG had higher graft loss secondary to infection ( P  = 0.0002) and thrombosis ( P  = 0.0213). Survival was less than 50% at 2 years for AVF and AVG patients. An equal number of AVF and AVG patients who died had functional access at the time of death ( P  = 1.0000) with more AVG patients using their graft (initiating dialysis) before death ( P  = 0.0118). Conclusions Elderly patient patency rates for AVF and AVG are satisfactory and support surgical access creation; however, overall 2-year survival is low. An equal number of AVF and AVG patients died with functioning surgical access, however, more AVG patients initiated dialysis and successfully used their access. Accordingly, special consideration needs to be given with regard to estimated timing until dialysis and predicted patient longevity. Delaying access creation until dialysis is needed and proceeding with AVG creation appears to be justified.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arteriovenous Shunt, Surgical - adverse effects</subject><subject>Arteriovenous Shunt, Surgical - instrumentation</subject><subject>Arteriovenous Shunt, Surgical - mortality</subject><subject>Blood Vessel Prosthesis - adverse effects</subject><subject>Blood Vessel Prosthesis Implantation - adverse effects</subject><subject>Blood Vessel Prosthesis Implantation - instrumentation</subject><subject>Blood Vessel Prosthesis Implantation - mortality</subject><subject>Female</subject><subject>Graft Occlusion, Vascular - etiology</subject><subject>Graft Occlusion, Vascular - physiopathology</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Prosthesis-Related Infections - microbiology</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency, Chronic - diagnosis</subject><subject>Renal Insufficiency, Chronic - mortality</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stents - adverse effects</subject><subject>Surgery</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - physiopathology</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vascular Patency</subject><issn>0890-5096</issn><issn>1615-5947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rFEEQhhtRkjXJH_AgffQyY9V89IeIEEI0QnAD0XPT21MTe52P2D2zMP8-PWz04MFTQfG8L9RTjL1ByBFQvN_n9hAf8gKwzkHlgOULtkGBdVbrSr5kG1Aashq0OGWvY9wDYKEqdcJOCyFQVFpv2Lcb6sfG226JPvJL5yhG7gc-_SR-3TUUuuUD386TG3uK3Pbj8MDv7ORpmCLfrkBC7cDv6ZBWyzl71dou0sXzPGM_Pl9_v7rJbrdfvl5d3mauQpyyHZR6J2WhnJJIoBqtS6F02UiwokVXkBa1VAIqC4hUWdnKnRatdiSQSJdn7N2x9zGMv2eKk-l9dNR1dqBxjgalKHStoYSEFkfUhTHGQK15DL63YTEIZvVo9mb1aFaPBpRJHlPo7XP_vOup-Rv5Iy4BH48ApSsPnoKJLklx1PhAbjLN6P_f_-mfuOv84J3tftFCcT_OYUj-DJpYGDD36yfXR2INILUuyieLwpff</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Jadlowiec, Caroline C</creator><creator>Mannion, Elizabeth M</creator><creator>Lavallee, Matthew</creator><creator>Brown, Matthew G</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7860-9519</orcidid></search><sort><creationdate>20160201</creationdate><title>Hemodialysis Access in the Elderly: Outcomes among Patients Older than Seventy</title><author>Jadlowiec, Caroline C ; Mannion, Elizabeth M ; Lavallee, Matthew ; Brown, Matthew G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-b039b7728c871e08d9936893d70a6f1c2e96578604a011e4a7f7b96f9ce61ee93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arteriovenous Shunt, Surgical - adverse effects</topic><topic>Arteriovenous Shunt, Surgical - instrumentation</topic><topic>Arteriovenous Shunt, Surgical - mortality</topic><topic>Blood Vessel Prosthesis - adverse effects</topic><topic>Blood Vessel Prosthesis Implantation - adverse effects</topic><topic>Blood Vessel Prosthesis Implantation - instrumentation</topic><topic>Blood Vessel Prosthesis Implantation - mortality</topic><topic>Female</topic><topic>Graft Occlusion, Vascular - etiology</topic><topic>Graft Occlusion, Vascular - physiopathology</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Prosthesis-Related Infections - microbiology</topic><topic>Renal Dialysis</topic><topic>Renal Insufficiency, Chronic - diagnosis</topic><topic>Renal Insufficiency, Chronic - mortality</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stents - adverse effects</topic><topic>Surgery</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - physiopathology</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vascular Patency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jadlowiec, Caroline C</creatorcontrib><creatorcontrib>Mannion, Elizabeth M</creatorcontrib><creatorcontrib>Lavallee, Matthew</creatorcontrib><creatorcontrib>Brown, Matthew G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jadlowiec, Caroline C</au><au>Mannion, Elizabeth M</au><au>Lavallee, Matthew</au><au>Brown, Matthew G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemodialysis Access in the Elderly: Outcomes among Patients Older than Seventy</atitle><jtitle>Annals of vascular surgery</jtitle><addtitle>Ann Vasc Surg</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>31</volume><spage>77</spage><epage>84</epage><pages>77-84</pages><issn>0890-5096</issn><eissn>1615-5947</eissn><abstract>Background Arteriovenous fistulae (AVF) are the preferred access for hemodialysis, however, there continues to be limited data guiding the surgical management of primary dialysis access creation in elderly end-stage renal disease patients. Methods This is an 8-year retrospective institutional study evaluating the operative and clinical characteristics of patients 70 years or above who underwent primary, first-ever, AVF or arteriovenous graft (AVG) creation. Results There was no overall significant difference in AVF and AVG primary ( P  = 0.127) and secondary ( P  = 0.870) patency. AVG had higher graft loss secondary to infection ( P  = 0.0002) and thrombosis ( P  = 0.0213). Survival was less than 50% at 2 years for AVF and AVG patients. An equal number of AVF and AVG patients who died had functional access at the time of death ( P  = 1.0000) with more AVG patients using their graft (initiating dialysis) before death ( P  = 0.0118). Conclusions Elderly patient patency rates for AVF and AVG are satisfactory and support surgical access creation; however, overall 2-year survival is low. An equal number of AVF and AVG patients died with functioning surgical access, however, more AVG patients initiated dialysis and successfully used their access. Accordingly, special consideration needs to be given with regard to estimated timing until dialysis and predicted patient longevity. Delaying access creation until dialysis is needed and proceeding with AVG creation appears to be justified.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>26616499</pmid><doi>10.1016/j.avsg.2015.08.013</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7860-9519</orcidid></addata></record>
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subjects Age Factors
Aged
Aged, 80 and over
Arteriovenous Shunt, Surgical - adverse effects
Arteriovenous Shunt, Surgical - instrumentation
Arteriovenous Shunt, Surgical - mortality
Blood Vessel Prosthesis - adverse effects
Blood Vessel Prosthesis Implantation - adverse effects
Blood Vessel Prosthesis Implantation - instrumentation
Blood Vessel Prosthesis Implantation - mortality
Female
Graft Occlusion, Vascular - etiology
Graft Occlusion, Vascular - physiopathology
Humans
Kaplan-Meier Estimate
Male
Prosthesis-Related Infections - microbiology
Renal Dialysis
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - mortality
Renal Insufficiency, Chronic - therapy
Retrospective Studies
Risk Factors
Stents - adverse effects
Surgery
Thrombosis - etiology
Thrombosis - physiopathology
Time Factors
Treatment Outcome
Vascular Patency
title Hemodialysis Access in the Elderly: Outcomes among Patients Older than Seventy
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