Nuclear Import and Export Signals in Control of Nrf2

Nrf2 binds to the antioxidant response element and regulates expression and antioxidant induction of a battery of chemopreventive genes. In this study, we have identified nuclear import and export signals of Nrf2 and show that the nuclear import and export of Nrf2 is regulated by antioxidants. We de...

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Veröffentlicht in:	The Journal of biological chemistry 2005-08, Vol.280 (32), p.29158-29168
Hauptverfasser:	Jain, Abhinav K., Bloom, David A., Jaiswal, Anil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Antibiotics, Antineoplastic - pharmacology Antioxidants - chemistry Antioxidants - pharmacology Bacterial Proteins - metabolism Biological Transport Cell Line Cell Line, Tumor Cell Nucleus - metabolism Cytosol - metabolism DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Electrophoresis, Polyacrylamide Gel Fatty Acids, Unsaturated - chemistry Gene Deletion Genes, Reporter Green Fluorescent Proteins - chemistry Green Fluorescent Proteins - metabolism Humans Immunoblotting Immunohistochemistry Luciferases - metabolism Luminescent Proteins - metabolism Microscopy, Fluorescence Mutation NF-E2-Related Factor 2 Nuclear Localization Signals Plasmids - metabolism Protein Binding Protein Structure, Tertiary Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Time Factors Trans-Activators - metabolism Trans-Activators - physiology Transfection
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