miR-146a and miR-638 in BRCA1-deficient triple negative breast cancer tumors, as potential biomarkers for improved overall survival

BACKGROUND: Mechanisms that lead to the reduced expression of BRCA1 in triple-negative breast cancer (TNBC) tumors are not fully understood. A possible cause is overexpression of miR-146a and miR-638, which regulate BRCA1 expression in other cancers. OBJECTIVE: To evaluate the expression of these mi...

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Veröffentlicht in:	Cancer biomarkers : section A of Disease markers 2016-01, Vol.16 (1), p.99-107
Hauptverfasser:	Zavala, Valentina, Pérez-Moreno, Elisa, Tapia, Teresa, Camus, Mauricio, Carvallo, Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers, Tumor BRCA1 Protein - deficiency BRCA2 Protein - genetics Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Germ-Line Mutation Humans MicroRNAs - genetics Middle Aged Neoplasm Grading Receptor, Epidermal Growth Factor - genetics Triple Negative Breast Neoplasms - diagnosis Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - mortality Young Adult
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