Design of an α-L-transfucosidase for the synthesis of fucosylated HMOs

Human milk oligosaccharides (HMOs) are recognized as benefiting breast-fed infants in multiple ways. As a result, there is growing interest in the synthesis of HMOs mimicking their natural diversity. Most HMOs are fucosylated oligosaccharides. α-l-Fucosidases catalyze the hydrolysis of α-l-fucose fr...

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Veröffentlicht in:	Glycobiology (Oxford) 2016-03, Vol.26 (3), p.261-269
Hauptverfasser:	Saumonneau, Amélie, Champion, Elise, Peltier-Pain, Pauline, Molnar-Gabor, Dora, Hendrickx, Johann, Tran, Vinh, Hederos, Markus, Dekany, Gyula, Tellier, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-L-Fucosidase - chemistry alpha-L-Fucosidase - genetics Amino Sugars - chemistry Bifidobacterium - enzymology Fucose - chemistry Glycosylation Humans Infant Milk, Human - chemistry Mutation - genetics Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Polysaccharides - chemistry Substrate Specificity
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