A novel, protective role of ursodeoxycholate in bile-induced pancreatic ductal injury

We have previously shown that chenodeoxycholic acid (CDCA) strongly inhibits pancreatic ductal HCO3 (-) secretion through the destruction of mitochondrial function, which may have significance in the pathomechanism of acute pancreatitis (AP). Ursodeoxycholic acid (UDCA) is known to protect the mitoc...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2016-02, Vol.310 (3), p.G193-G204
Hauptverfasser:	Katona, Máté, Hegyi, Péter, Kui, Balázs, Balla, Zsolt, Rakonczay, Jr, Zoltán, Rázga, Zsolt, Tiszlavicz, László, Maléth, József, Venglovecz, Viktória
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Apoptosis Apoptosis - drug effects Bile Bile Acids and Salts Calcium Signaling - drug effects Cell Death - drug effects Chenodeoxycholic Acid Epithelial Cells - drug effects Gastrointestinal Agents - therapeutic use Guinea Pigs Hydrogen-Ion Concentration In Vitro Techniques Male Membrane Potential, Mitochondrial - drug effects Mitochondria Mitochondria - drug effects Morphology Pancreas Pancreatic Ducts - injuries Pancreatitis - chemically induced Pancreatitis - prevention & control Physiology Rats Rats, Sprague-Dawley Ursodeoxycholic Acid - therapeutic use
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