Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus: e1005264

Sensing viruses by pattern recognition receptors (PRR) triggers the innate immune system of the host cell and activates immune signaling cascades such as the RIG-I/IRF3 pathway. Mitochondrial antiviral-signaling protein (MAVS, also known as IPS-1, Cardif, and VISA) is the crucial adaptor protein of...

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Veröffentlicht in:	PLoS pathogens 2015-11, Vol.11 (11)
Hauptverfasser:	Bender, Silke, Reuter, Antje, Eberle, Florian, Einhorn, Evelyne, Binder, Marco, Bartenschlager, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Defense mechanisms Endoplasmic reticulum Genes Genomics Hepatitis Hepatitis C virus Infections Interferon Liver diseases Localization Mitochondria Pattern recognition Proteins Viral infections
Online-Zugang:	Volltext
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