Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637

C-reactive protein (CRP), an acute-phase plasma protein, is a major component of inflammatory reactions functioning as a mediator of innate immunity. It has been widely used as a validated clinical biomarker of the inflammatory state in trauma, infection, and age-associated chronic diseases, includi...

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Veröffentlicht in:	Molecular and cellular biology 2015-12, Vol.35 (24), p.4212-4221
Hauptverfasser:	Kim, Yoonseo, Noren Hooten, Nicole, Dluzen, Douglas F., Martindale, Jennifer L., Gorospe, Myriam, Evans, Michele K.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Biomarkers - blood Biomarkers - metabolism C-Reactive Protein - genetics C-Reactive Protein - metabolism Cell Line, Tumor ELAV-Like Protein 1 - blood ELAV-Like Protein 1 - genetics ELAV-Like Protein 1 - metabolism Gene Expression Regulation, Neoplastic HeLa Cells Hep G2 Cells Humans Inflammation - genetics Inflammation - immunology Interleukin-6 - biosynthesis Interleukin-6 - genetics MicroRNAs - blood MicroRNAs - genetics RNA Interference RNA Processing, Post-Transcriptional - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
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