Incremental Cost-Effectiveness Analysis of Gestational Diabetes Mellitus Screening Strategies in Singapore
The objective of this study was to conduct an incremental cost-effectiveness analysis from the payer’s perspective in Singapore of 3 gestational diabetes mellitus screening strategies: universal, targeted, or no screening. A decision tree model assessed the primary outcome: incremental cost per qual...
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| Veröffentlicht in: | Asia-Pacific journal of public health 2016-01, Vol.28 (1), p.15-25 |
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| container_title | Asia-Pacific journal of public health |
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| creator | Chen, Pin Yu Finkelstein, Eric A. Ng, Mor Jack Yap, Fabian Yeo, George S. H. Rajadurai, Victor Samuel Chong, Yap Seng Gluckman, Peter D. Saw, Seang Mei Kwek, Kenneth Y. C. Tan, Kok Hian |
| description | The objective of this study was to conduct an incremental cost-effectiveness analysis from the payer’s perspective in Singapore of 3 gestational diabetes mellitus screening strategies: universal, targeted, or no screening. A decision tree model assessed the primary outcome: incremental cost per quality-adjusted life year (QALY) gained. Probabilities, costs, and utilities were derived from the literature, the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study, and the KK Women’s and Children’s Hospital’s database. Relative to targeted screening using risk factors, universal screening generates an incremental cost-effectiveness ratio (ICER) of $USD10 630/QALY gained. Sensitivity analyses show that disease prevalence rates and intervention effectiveness of glycemic management have the biggest impacts on the ICERs. Based on the model and best available data, universal screening is a cost-effective approach for reducing the complications of gestational diabetes mellitus in Singapore as compared with the targeted screening approach or no screening. |
| doi_str_mv | 10.1177/1010539515612908 |
| format | Article |
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H. ; Rajadurai, Victor Samuel ; Chong, Yap Seng ; Gluckman, Peter D. ; Saw, Seang Mei ; Kwek, Kenneth Y. C. ; Tan, Kok Hian</creator><creatorcontrib>Chen, Pin Yu ; Finkelstein, Eric A. ; Ng, Mor Jack ; Yap, Fabian ; Yeo, George S. H. ; Rajadurai, Victor Samuel ; Chong, Yap Seng ; Gluckman, Peter D. ; Saw, Seang Mei ; Kwek, Kenneth Y. C. ; Tan, Kok Hian</creatorcontrib><description>The objective of this study was to conduct an incremental cost-effectiveness analysis from the payer’s perspective in Singapore of 3 gestational diabetes mellitus screening strategies: universal, targeted, or no screening. A decision tree model assessed the primary outcome: incremental cost per quality-adjusted life year (QALY) gained. Probabilities, costs, and utilities were derived from the literature, the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study, and the KK Women’s and Children’s Hospital’s database. Relative to targeted screening using risk factors, universal screening generates an incremental cost-effectiveness ratio (ICER) of $USD10 630/QALY gained. Sensitivity analyses show that disease prevalence rates and intervention effectiveness of glycemic management have the biggest impacts on the ICERs. Based on the model and best available data, universal screening is a cost-effective approach for reducing the complications of gestational diabetes mellitus in Singapore as compared with the targeted screening approach or no screening.</description><identifier>ISSN: 1010-5395</identifier><identifier>EISSN: 1941-2479</identifier><identifier>DOI: 10.1177/1010539515612908</identifier><identifier>PMID: 26512030</identifier><language>eng</language><publisher>Los Angeles, CA: Sage Publications, Inc</publisher><subject>Cohort Studies ; Cost-Benefit Analysis ; Diabetes, Gestational - prevention & control ; Female ; Humans ; Mass Screening - economics ; Mass Screening - methods ; Models, Economic ; Original Article ; Pregnancy ; Quality-Adjusted Life Years ; Singapore</subject><ispartof>Asia-Pacific journal of public health, 2016-01, Vol.28 (1), p.15-25</ispartof><rights>2015 APJPH</rights><rights>2015 APJPH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-da5828df9ff16ce04ad719226bdfbafbb665c30c1e61e22cb16d1cb038aab82e3</citedby><cites>FETCH-LOGICAL-c458t-da5828df9ff16ce04ad719226bdfbafbb665c30c1e61e22cb16d1cb038aab82e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26686197$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26686197$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,21819,27924,27925,43621,43622,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26512030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Pin Yu</creatorcontrib><creatorcontrib>Finkelstein, Eric A.</creatorcontrib><creatorcontrib>Ng, Mor Jack</creatorcontrib><creatorcontrib>Yap, Fabian</creatorcontrib><creatorcontrib>Yeo, George S. H.</creatorcontrib><creatorcontrib>Rajadurai, Victor Samuel</creatorcontrib><creatorcontrib>Chong, Yap Seng</creatorcontrib><creatorcontrib>Gluckman, Peter D.</creatorcontrib><creatorcontrib>Saw, Seang Mei</creatorcontrib><creatorcontrib>Kwek, Kenneth Y. C.</creatorcontrib><creatorcontrib>Tan, Kok Hian</creatorcontrib><title>Incremental Cost-Effectiveness Analysis of Gestational Diabetes Mellitus Screening Strategies in Singapore</title><title>Asia-Pacific journal of public health</title><addtitle>Asia Pac J Public Health</addtitle><description>The objective of this study was to conduct an incremental cost-effectiveness analysis from the payer’s perspective in Singapore of 3 gestational diabetes mellitus screening strategies: universal, targeted, or no screening. A decision tree model assessed the primary outcome: incremental cost per quality-adjusted life year (QALY) gained. Probabilities, costs, and utilities were derived from the literature, the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study, and the KK Women’s and Children’s Hospital’s database. Relative to targeted screening using risk factors, universal screening generates an incremental cost-effectiveness ratio (ICER) of $USD10 630/QALY gained. Sensitivity analyses show that disease prevalence rates and intervention effectiveness of glycemic management have the biggest impacts on the ICERs. Based on the model and best available data, universal screening is a cost-effective approach for reducing the complications of gestational diabetes mellitus in Singapore as compared with the targeted screening approach or no screening.</description><subject>Cohort Studies</subject><subject>Cost-Benefit Analysis</subject><subject>Diabetes, Gestational - prevention & control</subject><subject>Female</subject><subject>Humans</subject><subject>Mass Screening - economics</subject><subject>Mass Screening - methods</subject><subject>Models, Economic</subject><subject>Original Article</subject><subject>Pregnancy</subject><subject>Quality-Adjusted Life Years</subject><subject>Singapore</subject><issn>1010-5395</issn><issn>1941-2479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFvFDEMhSMEoqVw5wLKkctAnJlkJsdqKaVSEYeF8yjJOKusZidLnKnUf0-qLQhxQFxsy-_zk2Uz9hrEe4C-_wAChGqNAqVBGjE8YedgOmhk15unta5y86CfsRdEeyGUGYR5zs6kViBFK87Z_mbxGQ-4FDvzTaLSXIWAvsQ7XJCIXy52vqdIPAV-jVRsiam2-MdoHRYk_gXnOZaV-Lb64BKXHd-WbAvuYlXjwre1ZY8p40v2LNiZ8NVjvmDfP11923xubr9e32wubxvfqaE0k1WDHKZgQgDtUXR26sFIqd0UnA3Oaa18KzygBpTSO9ATeCfawVo3SGwv2LuT7zGnH2vdeTxE8nVNu2BaaYRey7bXNfwPKgy0qjMVFSfU50SUMYzHHA82348gxodnjH8_o468fXRf3QGn3wO_rl-B5gSQ3eG4T2uup6V_Gb458XsqKf_hpwcNpm9_AlF4nHs</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Chen, Pin Yu</creator><creator>Finkelstein, Eric A.</creator><creator>Ng, Mor Jack</creator><creator>Yap, Fabian</creator><creator>Yeo, George S. H.</creator><creator>Rajadurai, Victor Samuel</creator><creator>Chong, Yap Seng</creator><creator>Gluckman, Peter D.</creator><creator>Saw, Seang Mei</creator><creator>Kwek, Kenneth Y. C.</creator><creator>Tan, Kok Hian</creator><general>Sage Publications, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20160101</creationdate><title>Incremental Cost-Effectiveness Analysis of Gestational Diabetes Mellitus Screening Strategies in Singapore</title><author>Chen, Pin Yu ; Finkelstein, Eric A. ; Ng, Mor Jack ; Yap, Fabian ; Yeo, George S. H. ; Rajadurai, Victor Samuel ; Chong, Yap Seng ; Gluckman, Peter D. ; Saw, Seang Mei ; Kwek, Kenneth Y. 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C.</au><au>Tan, Kok Hian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incremental Cost-Effectiveness Analysis of Gestational Diabetes Mellitus Screening Strategies in Singapore</atitle><jtitle>Asia-Pacific journal of public health</jtitle><addtitle>Asia Pac J Public Health</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>28</volume><issue>1</issue><spage>15</spage><epage>25</epage><pages>15-25</pages><issn>1010-5395</issn><eissn>1941-2479</eissn><abstract>The objective of this study was to conduct an incremental cost-effectiveness analysis from the payer’s perspective in Singapore of 3 gestational diabetes mellitus screening strategies: universal, targeted, or no screening. A decision tree model assessed the primary outcome: incremental cost per quality-adjusted life year (QALY) gained. 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| subjects | Cohort Studies Cost-Benefit Analysis Diabetes, Gestational - prevention & control Female Humans Mass Screening - economics Mass Screening - methods Models, Economic Original Article Pregnancy Quality-Adjusted Life Years Singapore |
| title | Incremental Cost-Effectiveness Analysis of Gestational Diabetes Mellitus Screening Strategies in Singapore |
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