The role of purinergic and dopaminergic systems on MK-801-induced antidepressant effects in zebrafish

Depression is a serious disease characterized by low mood, anhedonia, loss of interest in daily activities, appetite and sleep disturbances, reduced concentration, and psychomotor agitation. There is a growing interest in NMDA antagonists as a promising target for the development of new antidepressa...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2015-12, Vol.139, p.149-157
Hauptverfasser:	da Silva, Raquel Bohrer, Siebel, Anna Maria, Bonan, Carla Denise
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - physiology Adenosine A1 Receptor Agonists - pharmacology Adenosine A1 Receptor Antagonists - pharmacology Adenosine A2 Receptor Agonists - pharmacology Adenosine A2 Receptor Antagonists - pharmacology Adenosine deaminase Adenosine receptors Animals Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Behavior, Animal - drug effects Behavior, Animal - physiology Danio rerio Dizocilpine Maleate - administration & dosage Dizocilpine Maleate - pharmacology Dopamine Dopamine Antagonists - pharmacology Dopaminergic Neurons - drug effects Dopaminergic Neurons - physiology Ecto-5’′-nucleotidase MK-801 Nucleoside transporters Receptors, Purinergic - drug effects Receptors, Purinergic - physiology Zebrafish - physiology
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