Protective effects of taurine on doxorubicin-induced acute hepatotoxicity through suppression of oxidative stress and apoptotic responses

The organ toxicity of doxorubicin (DOX), an anthracycline antineoplastic agent, narrows the therapeutic window despite its clinical usefulness. In the present study, we determined whether taurine protected against DOX-induced hepatic injury, and explored the molecular mechanisms underlying the suppr...

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Veröffentlicht in:	Anti-cancer drugs 2016-01, Vol.27 (1), p.17-23
Hauptverfasser:	Nagai, Katsuhito, Fukuno, Shuhei, Oda, Ayano, Konishi, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - metabolism Animals Antibiotics, Antineoplastic - toxicity Apoptosis - drug effects Aspartate Aminotransferases - metabolism Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Doxorubicin - toxicity Glutathione - metabolism L-Lactate Dehydrogenase - metabolism Male Mice Oxidative Stress - drug effects Superoxide Dismutase - metabolism Taurine - therapeutic use
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